The Implementation of the Three Rs in Regulatory Toxicity and Biosafety Assessment: The Indian Perspective

Animal fashions have lengthy served as a foundation for scientific experimentation, biomedical analysis, drug growth and testing, illness modelling and toxicity research, as they’re extensively thought to offer significant, human-relevant predictions. Nonetheless, many of those techniques are useful resource intensive and time-consuming, have low predictive worth and are related to nice social and moral dilemmas. Typically medication look like efficient and protected in these classical animal fashions, however later show to be ineffective and/or unsafe in medical trials. These points have paved the way in which for a paradigm shift from using in vivo approaches, towards the ‘science of alternate options’.

This has fuelled a number of analysis and regulatory initiatives, together with the ban on the testing of cosmetics on animals. The brand new paradigm has been shifted towards rising the relevance of the fashions for human predictivity and translational efficacy, and this has resulted within the latest growth of many new methodologies, from 3-D bio-organoids to bioengineered ‘human-on-a-chip’ fashions. These enhancements have the potential to considerably advance medical analysis globally.

This paper affords a stance on the present methods and practices that utilise alternate options to animals, and descriptions progress on the incorporation of those fashions into primary and utilized analysis and schooling, particularly in India. It additionally seeks to offer a strategic roadmap to streamline the longer term instructions for the nation’s coverage modifications and investments. This strategic roadmap could possibly be a helpful useful resource to information analysis establishments, industries, regulatory companies, contract analysis organisations and different stakeholders in transitioning towards fashionable approaches to security and threat evaluation that would exchange or cut back using animals with out compromising the security of people or the setting.

The Summer time College Oncology Groningen: Enhancing a Profitable Worldwide Course by Refining the Previous, Sustaining What’s Good

For greater than 20 years, the Worldwide Summer time College Oncology for Medical College students (ISOMS) has organized a biennial 2-week worldwide summer time faculty program in Groningen, the Netherlands. The summer time faculty goals to extend data about normal most cancers care, cut back concern of speaking to most cancers sufferers, and expose college students to cancer-related issues. After 22 years, there was a necessity to enhance the summer time faculty format, the appliance process, and the depth of the course. Right here, we describe and consider these and extra modifications that have been made to this system. A number of modifications have been made to the summer time faculty format.

The course was shortened from 10 days to a extra intensive 7 days. The scientific program was built-in with the medical program and college students have been taught scientific writing and presentation abilities. The applying course of concerned a private video pitch. Importantly, the brand new summer time faculty format was organized by a committee wherein medical college students had the lead. To guage the modifications to the summer time faculty, we carried out data checks and frequently obtained suggestions.

There was a excessive total scholar satisfaction, with a median rating of a 9 out of 10. College students appreciated the interactive periods and practicals and the scientific program, and have been glad with the course degree. All college students had improved take a look at scores. Enchancment factors highlighted the necessity for a much less packed schedule and extra lectures on primary oncology rules, or have been associated to particular lectures. The coed-led innovation and adaptation of the ISOMS has been profitable.

Limitations and techniques to combine medical genetics and first care in underserved populations: a scoping evaluation

Regardless of medical and technological advances, severe gaps stay in delivering genetic providers as a result of disparities in workforce distribution and lack of protection for genetic testing and counseling. Genetic providers supply, significantly in medically underserved populations, might rely closely on major care suppliers (PCPs). This examine goals to determine obstacles to integrating genetic providers and first care, and techniques to assist integration, by conducting a scoping evaluation. Literature synthesis discovered obstacles most ceaselessly cited by PCPs together with inadequate data about genetics and threat evaluation, lack of entry to geneticists, and inadequate time to deal with these challenges.

Telegenetics, patient-centered care, and studying communities are methods to beat these obstacles. Telegenetics dietary supplements face-to-face clinics by offering distant entry to genetic providers. It could even be used for doctor consultations and schooling. Affected person-centered care permits suppliers, households, and sufferers to coordinate providers and sources.

Entry to professional data offers a crucial useful resource for PCPs. Studying communities might characterize a mechanism that facilitates data alternate and data sharing amongst totally different suppliers. As PCPs typically play a vital position caring for sufferers with genetic issues in underserved areas, obstacles to major care-medical genetics integration should be addressed to enhance entry.

pGreenFire1-Notch (virus)
TR020VA-1	SBI	>2 x 10^6 IFUs	EUR 943.2

Anti-Cleaved-Notch 1 (V1754) Antibody
A00033-1	BosterBio	100ul	EUR 476.4
Description: Rabbit Polyclonal Antibody for Cleaved-Notch 1 (V1754) Antibody (NOTCH1) detection.tested for WB in Human, Mouse, Rat.

Rat IgG (Fc)-Biotin Conjuagte (isotype control), purified
20005-1-FC-B	Alpha Diagnostics	0.1 mg	EUR 270

Rat IgG (Fc)-FITC Conjuagte (isotype control), purified
20005-1-FC-F	Alpha Diagnostics	0.1 mg	EUR 270

Rat IgG (Fc)-HRP Conjuagte (isotype control), purified
20005-1-FC-HP	Alpha Diagnostics	0.1 mg	EUR 270

Human IgG (Fc) fragment, purified (>95%, low endotoxin)
20007-1-FC-LE	Alpha Diagnostics	100 ul	EUR 270

Sheep IgG-Fc ELISA Kit, 96 tests, Quantitative
7615-Fc	Alpha Diagnostics	1 kit	EUR 854.4

Horse IgG-Fc ELISA Kit, 96 tests, Quantitative
7715-Fc	Alpha Diagnostics	1 kit	EUR 854.4

Dog IgG (Fc) fragment (isotype control, non-immune), purified
20016-FC	Alpha Diagnostics	0.5 mg	EUR 300

Human IgG Fc-Biotin conjugate (isotype control, non-immune), purified
20007-1-Fc-B	Alpha Diagnostics	0.1 mg	EUR 196.8

Human IgG Fc-FITC conjugate (isotype control, non-immune), purified
20007-1-Fc-F	Alpha Diagnostics	0.1 mg	EUR 196.8

Human IgG Fc-HRP conjugate (isotype control, non-immune), purified
20007-1-Fc-HP	Alpha Diagnostics	0.1 mg	EUR 196.8

IGF-1-Fc
E13-m003-1	EnoGene	10μg	EUR 349.2

SARS-CoV-2 Spike S1 RBD Protein, Mouse Fc-fusion
E80026	EpiGentek	EUR 588.50 EUR 823.90	20 ul 50 ul

Recombinant (HEK) Rabbit IgG (Fc) (101-323aa, 185Thr/Asn284Ser, ~33 kda, >95%, Low Endotoxin)
20009-1-R-FC	Alpha Diagnostics	50 ug	EUR 343.2

Human IgG (Fc) fragment-Biotin purified (>95%, low endotoxin)
20007-1-FC-LE-B	Alpha Diagnostics	25 ug	EUR 343.2

Goat IgG (fc)-Biotin conjugate (isotype control)
20011-Fc-B	Alpha Diagnostics	100 ug	EUR 196.8

Goat IgG (fc)-FITC conjugate (isotype control)
20011-Fc-F	Alpha Diagnostics	100 ug	EUR 196.8

Goat IgG (fc)-HRP conjugate (isotype control)
20011-Fc-HP	Alpha Diagnostics	100 ug	EUR 196.8

SARS-CoV-2 Spike S1 (13-665) Protein, Fc Fusion, Avi-tag
E80020	EpiGentek	EUR 635.80 EUR 4276.80	100 ul 1 ml

SARS-CoV-2 Spike S1 (16-685) Protein, Fc Fusion, Avi-tag
E80022	EpiGentek	EUR 635.80 EUR 4276.80	100 ul 1 ml

SARS-CoV-2 Spike S1 RBD Protein, Human Fc-Fusion, Avi-Tag
E80025	EpiGentek	EUR 635.80 EUR 3934.70	100 ul 1 ml

FC 131
B7647-1	ApexBio	1 mg	EUR 224.4

Notch 1 antibody
70R-31090	Fitzgerald	100 ug	EUR 392.4
Description: Rabbit polyclonal Notch 1 antibody

Notch 1 Antibody
48766-100ul	SAB	100ul	EUR 399.6

Notch 1 Antibody
48766-50ul	SAB	50ul	EUR 286.8

Notch 1 antibody
70R-12158	Fitzgerald	100 ug	EUR 483.6
Description: Rabbit polyclonal Notch 1 antibody

Notch 1 antibody
10R-6539	Fitzgerald	50 ug	EUR 230.4
Description: Mouse monoclonal Notch 1 antibody

Notch 1 antibody
20R-1749	Fitzgerald	100 ug	EUR 807.6
Description: Rabbit polyclonal Notch 1 antibody

Notch 1 Antibody
abx139789-01mg	Abbexa	0.1 mg	EUR 427.2

Notch 1 Antibody
3881-100	Biovision	each	EUR 379.2

Notch 1 Antibody
3881-30T	Biovision	each	EUR 175.2

Dog IgG (Fc) fragment (isotype control, non-immune), purified
20016-3-FC	Alpha Diagnostics	0.5 mg	EUR 300

Dog IgG Fc-Biotin Conjugate (isotype control, non-immune), purified
20016-FC-B	Alpha Diagnostics	0.1 mg	EUR 270

Dog IgG Fc-FITC Conjugate (isotype control, non-immune), purified
20016-FC-F	Alpha Diagnostics	0.1 mg	EUR 270

Dog IgG Fc-HRP Conjugate (isotype control, non-immune), purified
20016-FC-HP	Alpha Diagnostics	0.1 mg	EUR 270

OPG-Fc Osteoprotegerin Human Recombinant Protein /Fc Chimera
PROTO00300-1	BosterBio	Regular: 50ug	EUR 380.4
Description: Recombinant OPG produced in yeast contains 2x412 amino acid residues, including 180 residues from mature OPG (a.a 22-201) and 232 residues from the Fc protein of human IgG1, and has a calculated molecular mass of 109.6kDa.

SCF-Fc
E13-m004-1	EnoGene	10μg	EUR 411.6

Recombinant (HEK) Human IgG3-Fc (99-377aa, His-tag, >95%, low endotoxin)
20007-G3-FC	Alpha Diagnostics	50 ug	EUR 343.2

Notch 1 Conjugated Antibody
C48766	SAB	100ul	EUR 476.4

Notch 1 homolog antibody
70R-NR026	Fitzgerald	100 ug	EUR 360
Description: Affinity purified Rabbit polyclonal Notch 1 homolog antibody

Notch 1 antibody (PE)
61R-1347	Fitzgerald	100 ug	EUR 424.8
Description: Mouse monoclonal Notch 1 antibody (PE)

Notch 1 Blocking Peptide
33R-10562	Fitzgerald	50 ug	EUR 418.8
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Notch 1 antibody, catalog no. 20R-1749

Notch 1 Blocking Peptide
33R-10970	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Notch 1 antibody, catalog no. 70R-12158

Notch 1 Antibody (APC)
abx139790-01mg	Abbexa	0.1 mg	EUR 510

Notch 1 Antibody (PE)
abx139791-01mg	Abbexa	0.1 mg	EUR 510

Anti-NOTCH 1 Antibody
A00033	BosterBio	200uL	EUR 573.6
Description: Rabbit Polyclonal NOTCH 1 Antibody. Validated in IHC, WB and tested in Human.

Polyclonal Notch 1 Antibody
AMM06725G	Leading Biology	0.1mg	EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Notch 1 . This antibody is tested and proven to work in the following applications:

Notch-1, mouse recombinant
7530-25	Biovision	each	EUR 366

Notch 1 Blocking Peptide
3881BP-50	Biovision	each	EUR 183.6

Recombinant (HEK) Human IgG1 Fc (103Cys/Ser, 99-330aa, His-tag, >95%, low endotoxin)
20007-G1-FC	Alpha Diagnostics	50 ug	EUR 343.2

Recombinant (HEK) Human IgG2-Fc (257Ser/Ala, 99-327aa, His-tag, >95%, low endotoxin)
20007-G2-FC	Alpha Diagnostics	50 ug	EUR 343.2

Recombinant (HEK) Human IgG4-Fc (108Ser/Pro, 99-327aa, His-tag, >95%, low endotoxin)
20007-G4-FC	Alpha Diagnostics	50 ug	EUR 343.2

Recombinant (HEK) Mouse IgG2a-Fc (98-330aa, ~34 kda, His-tag, >95%, low endotoxin)
20102-102-FC	Alpha Diagnostics	50 ug	EUR 343.2

Recombinant (HEK) Mouse IgG2b-Fc (97-335aa, ~37 kda, His-tag, >95%, low endotoxin)
20102-103-FC	Alpha Diagnostics	50 ug	EUR 343.2

Recombinant (HEK) Mouse IgG3-Fc (97-329aa, ~33 kda, His-tag, >95%, low endotoxin)
20102-104-FC	Alpha Diagnostics	50 ug	EUR 343.2

Mouse Notch-1(Neurogenic locus notch homolog protein 1) ELISA Kit
EM1527	FN Test	96T	EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 4.688pg/ml

Recombinant Human CD47 Protein, His-Fc (IgG), Insect-10ug
QP11336-HIS-Fc-10ug	EnQuireBio	10ug	EUR 241.2

SDF-1α-Fc
E13-m001-1	EnoGene	10μg	EUR 349.2

VEGF-121-Fc
E13-m005-1	EnoGene	10μg	EUR 411.6

VEGF-165-Fc
E13-m006-1	EnoGene	10μg	EUR 411.6

IL-2-Fc
E13-m007-1	EnoGene	10μg	EUR 372

NOTCH Antibody
F53063-0.4ML	NSJ Bioreagents	0.4 ml	EUR 379

Recombinant (HEK) Mouse IgG1-Fc (98-321aa, 102Cys/Ser, ~32 kda, His-tag, >95%, low endotoxin)
20102-101-FC	Alpha Diagnostics	50	EUR 343.2

Notch-1 ELISA Kit| Mouse Neurogenic locus notch homolog protein
EF014010	Lifescience Market	96 Tests	EUR 826.8

PinPoint-FC attP Placement Vector
PIN300A-1	SBI	10ug	EUR 933.6

Cleaved-Notch 1 (Val1744) Antibody
AF5307	Affbiotech	200ul	EUR 420

Notch 1 (Cleaved-Val1754) Antibody
20-abx015544	Abbexa	EUR 376.80 EUR 117.60 EUR 477.60 EUR 594.00	100 ug 10 ug 200 ug 300 µg

Notch 1 (Cleaved- Val1744) Antibody
ABF5307	Lifescience Market	100 ug	EUR 525.6

Notch 1 (Cleaved-Val1744) Antibody
abx217212-100ug	Abbexa	100 ug	EUR 526.8

Notch-1 (human) ELISA Kit
K4763-100	Biovision	100 assays	EUR 970.8
Description: Sensitive, Colorimetric Assay

FLT4-Fc Vascular Endothelial Growth Factor Receptor-3 Fc Chimera Human Recombinant Protein
PROTP35916-1	BosterBio	Regular: 10ug	EUR 380.4
Description: Soluble FLT4 Human Recombinant fused with the Fc part of human IgG1 produced in baculovirus is a monomeric, glycosylated, polypeptide containing 774 amino acids and having a molecular mass of 260 kDa. The soluble receptor protein contains only the first 7 extracellular domains, which contain all the information necessary for ligand binding.;The FLT4 Fc Chimera is purified by proprietary chromatographic techniques.

Recombinant Human FGFR1a (IIIc) Fc Protein
PROTP11362-1	BosterBio	50ug	EUR 380.4
Description: The FGF family plays a central role during prenatal development and postnatal growth, and the regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. The FGF ligands bind to a family of type I transmembrane tyrosine kinase receptors which leads to dimerization and activation by sequential autophosphorylation of specific tyrosine residues. Four genes encoding structurally related FGF receptors (FGFR-1 to -4) are known. Alternative splicing of the mRNAs generates numerous multiple forms of FGFR-1 to -3. Alternate forms of FGF receptors can exhibit different specificities with respect to ligand binding. For example, the form designated as FGFR1a (IIc) interacts predominantly with FGF-acidic (FGF1) and FGF-basic (FGF2). A frequent splicing event involving FGFR-1 and -2 results in receptors containing all three Ig domains, referred to as the alpha isoform, or only IgII and IgIII, referred to as the beta isoform. Only the alpha isoform has been identified for FGFR-3 and FGFR-4. Additional splicing events for FGFR-1 to -3, involving the C-terminal half of the IgIII domain encoded by two mutually exclusive alternative exons, generate FGF receptors with alternative IgIII domains (IIIb and IIIc). Recombinant human FGFR1a (IIIc) is a 65.2 kDa protein containing 586 amino acids. Under reducing conditions, FGFR1a migrates between 100-110 kDa on SDS-PAGE gel.

TNFRSF14 HVEM-Fc Human Recombinant Protein
PROTO43557-1	BosterBio	Regular: 100ug	EUR 380.4
Description: TNFRSF14 Human Recombinant produced in Pichia Pastoris is a single, glycosylated, polypeptide chain containing 396 amino acids and having a molecular mass of 58.0kDa.

Notch 2 antibody
70R-31091	Fitzgerald	100 ug	EUR 392.4
Description: Rabbit polyclonal Notch 2 antibody

anti-Notch 2
YF-PA24259	Abfrontier	50 ul	EUR 400.8
Description: Mouse polyclonal to Notch 2

Human EPOR / Erythropoietin Receptor Protein (Fc Tag)
G1011-.1	ApexBio	100 µg	EUR 835.2

Human Notch Homolog 1 ELISA kit
E01N0594-192T	BlueGene	192 tests	EUR 1524
Description: A sandwich ELISA for quantitative measurement of Human Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Notch Homolog 1 ELISA kit
E01N0594-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A sandwich ELISA for quantitative measurement of Human Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Notch Homolog 1 ELISA kit
E01N0594-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A sandwich ELISA for quantitative measurement of Human Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Notch 1 (Cleaved-Val1744) Blocking Peptide
AF5307-BP	Affbiotech	1mg	EUR 234

Goat Notch Homolog 1 ELISA kit
E06N0594-192T	BlueGene	192 tests	EUR 1524
Description: A sandwich ELISA for quantitative measurement of Goat Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Notch Homolog 1 ELISA kit
E06N0594-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A sandwich ELISA for quantitative measurement of Goat Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Notch Homolog 1 ELISA kit
E06N0594-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A sandwich ELISA for quantitative measurement of Goat Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Notch Homolog 1 ELISA kit
E08N0594-192T	BlueGene	192 tests	EUR 1524
Description: A sandwich ELISA for quantitative measurement of Canine Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Notch Homolog 1 ELISA kit
E08N0594-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A sandwich ELISA for quantitative measurement of Canine Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Notch Homolog 1 ELISA kit
E08N0594-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A sandwich ELISA for quantitative measurement of Canine Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Notch Homolog 1 ELISA kit
E03N0594-192T	BlueGene	192 tests	EUR 1524
Description: A sandwich ELISA for quantitative measurement of Mouse Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Notch Homolog 1 ELISA kit
E03N0594-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A sandwich ELISA for quantitative measurement of Mouse Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Notch Homolog 1 ELISA kit
E03N0594-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A sandwich ELISA for quantitative measurement of Mouse Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Notch Homolog 1 ELISA kit
E04N0594-192T	BlueGene	192 tests	EUR 1524
Description: A sandwich ELISA for quantitative measurement of Rabbit Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Notch Homolog 1 ELISA kit
E04N0594-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A sandwich ELISA for quantitative measurement of Rabbit Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Notch Homolog 1 ELISA kit
E04N0594-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A sandwich ELISA for quantitative measurement of Rabbit Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Notch Homolog 1 ELISA kit
E07N0594-192T	BlueGene	192 tests	EUR 1524
Description: A sandwich ELISA for quantitative measurement of Porcine Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Notch Homolog 1 ELISA kit
E07N0594-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A sandwich ELISA for quantitative measurement of Porcine Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Notch Homolog 1 ELISA kit
E07N0594-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A sandwich ELISA for quantitative measurement of Porcine Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Notch Homolog 1 ELISA kit
E02N0594-192T	BlueGene	192 tests	EUR 1524
Description: A sandwich ELISA for quantitative measurement of Rat Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Notch Homolog 1 ELISA kit
E02N0594-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A sandwich ELISA for quantitative measurement of Rat Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Notch Homolog 1 ELISA kit
E02N0594-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A sandwich ELISA for quantitative measurement of Rat Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Cleaved-Notch 1 (V1754) Polyclonal Antibody
ES1050-100ul	ELK Biotech	100ul	EUR 334.8
Description: A Rabbit Polyclonal antibody against Cleaved-Notch 1 (V1754) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IF, IHC, WB, ELISA

Cleaved-Notch 1 (V1754) Polyclonal Antibody
ES1050-50ul	ELK Biotech	50ul	EUR 248.4
Description: A Rabbit Polyclonal antibody against Cleaved-Notch 1 (V1754) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IF, IHC, WB, ELISA

Cleaved-Notch 1 (V1754) Polyclonal Antibody
40516-100ul	SAB	100ul	EUR 302.4

Cleaved-Notch 1 (V1754) Polyclonal Antibody
40516-50ul	SAB	50ul	EUR 224.4

Strawberry Notch Homolog 1 (SBNO1) Antibody
abx122008-100ug	Abbexa	100 ug	EUR 469.2

NOTCH homolog 1 (NOTCH1) polyclonal antibody
ABP-PAB-10681	Allele Biotech	100 ug	Ask for price

Cleaved-Notch 1 (V1754) Polyclonal Antibody
ABP50051-003ml	Abbkine	0.03ml	EUR 189.6
Description: A polyclonal antibody for detection of Cleaved-Notch 1 V1754) from Human, Mouse, Rat. This Cleaved-Notch 1 V1754) antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Notch 1 at AA range: 1710-1790

Cleaved-Notch 1 (V1754) Polyclonal Antibody
ABP50051-01ml	Abbkine	0.1ml	EUR 346.8
Description: A polyclonal antibody for detection of Cleaved-Notch 1 V1754) from Human, Mouse, Rat. This Cleaved-Notch 1 V1754) antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Notch 1 at AA range: 1710-1790

Cleaved-Notch 1 (V1754) Polyclonal Antibody
ABP50051-02ml	Abbkine	0.2ml	EUR 496.8
Description: A polyclonal antibody for detection of Cleaved-Notch 1 V1754) from Human, Mouse, Rat. This Cleaved-Notch 1 V1754) antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Notch 1 at AA range: 1710-1790

Strawberry Notch Homolog 1 (SBNO1) Antibody
abx237618-100ug	Abbexa	100 ug	EUR 610.8

Monkey Notch Homolog 1 ELISA kit
E09N0594-192T	BlueGene	192 tests	EUR 1524
Description: A sandwich ELISA for quantitative measurement of Monkey Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Notch Homolog 1 ELISA kit
E09N0594-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A sandwich ELISA for quantitative measurement of Monkey Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Notch Homolog 1 ELISA kit
E09N0594-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A sandwich ELISA for quantitative measurement of Monkey Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

TranslationBlocker Human Notch-1 siRNA, 10nmol
QX37-10nmol	EnQuireBio	10nmol	EUR 452.4

TranslationBlocker Human Notch-1 siRNA, 2nmol
QX37-2nmol	EnQuireBio	2nmol	EUR 331.2

Anti-Cleaved-Notch 1 (V1754) antibody
STJ90066	St John's Laboratory	200 µl	EUR 236.4
Description: Notch 1 is a protein encoded by the NOTCH1 gene which is approximately 272,5 kDa. Notch 1 is localised to the cell membrane. It is involved in the notch signalling pathway and Notch 2 activation and transmission of signal to the nucleus. It functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Notch 1 is expressed in most adult tissues but is found mainly in lymphoid tissues. Mutations in the NOTCH1 gene may result in aortic valve disease and Adams-Oliver syndrome. STJ90066 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of fragment of activated Notch 1 protein resulting from cleavage adjacent to V1754.

Anti-Notch 1 (Cleaved-Val1744) Antibody
A1619-100	Biovision	each	EUR 574.8

IGF-1-Fc
E13-m003-2	EnoGene	50μg	EUR 996

Human Neurogenic locus notch homolog protein 1(NOTCH1) ELISA kit
1-CSB-EL015949HU	Cusabio	EUR 964.80 EUR 6118.80 EUR 3244.80	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitative sandwich ELISA kit for measuring Human Neurogenic locus notch homolog protein 1(NOTCH1) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

TEK Tyrosine Kinase Endothelial Fc Chimera Mouse Recombinant Protein
PROTQ02858-1	BosterBio	Regular: 10ug	EUR 380.4
Description: Soluble TEK Mouse Recombinant fused with the Fc part of human IgG1 produced in CHO is a glycosylated disulfide-linked homodimer, polypeptide containing amino acids 119-740 amino acids and having a total molecular mass of 280 kDa. Mouse TIE-2/Fc monomer has a calculated molecular mass of approximately 105 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 140 kDa protein in SDS-PAGE under reducing conditions.;The TEK Fc Chimera is purified by proprietary chromatographic techniques.

Guinea pig Notch Homolog 1 ELISA kit
E05N0594-192T	BlueGene	192 tests	EUR 1524
Description: A sandwich ELISA for quantitative measurement of Guinea pig Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Notch Homolog 1 ELISA kit
E05N0594-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A sandwich ELISA for quantitative measurement of Guinea pig Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Notch Homolog 1 ELISA kit
E05N0594-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A sandwich ELISA for quantitative measurement of Guinea pig Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Nori® Human Notch-1 ELISA Kit
GR106384	Genorise Scientific	96-well	EUR 553.2

Notch 2 homolog antibody
70R-NR027	Fitzgerald	100 ug	EUR 360
Description: Affinity purified Rabbit polyclonal Notch 2 homolog antibody

Notch 3 homolog antibody
70R-NR028	Fitzgerald	100 ug	EUR 360
Description: Affinity purified Rabbit polyclonal Notch 3 homolog antibody

Notch 4 homolog antibody
70R-NR029	Fitzgerald	100 ug	EUR 360
Description: Affinity purified Rabbit polyclonal Notch 4 homolog antibody

Notch 3 antibody (PE)
61R-1343	Fitzgerald	100 ug	EUR 528
Description: Armenian Hamster monoclonal Notch3 antibody (PE)

Notch 4 antibody (PE)
61R-1344	Fitzgerald	25 ug	EUR 249.6
Description: Armenian Hamster monoclonal Notch4 antibody (PE)

Notch 3 (NOTCH3) Antibody
20-abx214675	Abbexa	EUR 493.20 EUR 360.00	100 ul 50 ul

Anti-NOTCH 2 Antibody
A00518	BosterBio	200uL	EUR 583.2
Description: Rabbit Polyclonal NOTCH 2 Antibody. Validated in IHC, WB and tested in Human.

Human Notch Signaling Pathway
HNOT-I	Real Time Primers	1 set	EUR 657.6

Notch-2, mouse recombinant
7531-25	Biovision	each	EUR 366

Anti-NOTCH 2 Antibody
A1652-100	Biovision	each	EUR 444

Anti-NOTCH 3 Antibody
A1653-100	Biovision	each	EUR 444

FGFR2 Fibroblast Growth Factor Receptor 2 Fc ChimeraHuman Recombinant Protein
PROTP21802-1	BosterBio	Regular: 10ug	EUR 380.4
Description: Soluble FGFR-2a (IIIc) Fc Chimera Human Recombinant fused with Xa cleavage site with the Fc part of human IgG1 produced in baculovirus is a heterodimeric, glycosylated, Polypeptide chain and having a molecular mass of 195 kDa. ;The FGFR2 is purified by proprietary chromatographic techniques.

SARS-CoV-2 Spike S1 RBD Protein, Mouse Fc-fusion
E80026-1	EpiGentek	20 ul	EUR 588.5

Histone H3 Methylation Antibody Panel Pack I – Active Genes
C10000	EpiGentek	EUR 928.26 EUR 588.50	4 x 25 µg 4 x 25 ul

Histone H3 Methylation Antibody Panel Pack I – Repression Genes
C10001	EpiGentek	EUR 928.26 EUR 588.50	4 x 25 µg 4 x 25 ul

Histone H3 Methylation Antibody Panel Pack II – Active Genes
C10002	EpiGentek	EUR 754.26 EUR 470.80	3 x 25 µg 3 x 25 ul

Histone H3 Methylation Antibody Panel Pack II – Repression Genes
C10003	EpiGentek	EUR 928.26 EUR 588.50	4 x 25 µg 4 x 25 ul

Histone H3 Methylation Antibody Panel Pack III – Active Genes
C10004	EpiGentek	EUR 928.26 EUR 588.50	4 x 25 µg 4 x 25 ul

Histone H3K4 Methylation Antibody Panel Pack
C10005	EpiGentek	EUR 754.26 EUR 470.80	3 x 25 µg 3 x 25 ul

Histone H3K9 Methylation Antibody Panel Pack
C10006	EpiGentek	EUR 754.26 EUR 470.80	3 x 25 µg 3 x 25 ul

Histone H3K27 Methylation Antibody Panel Pack
C10007	EpiGentek	EUR 754.26 EUR 470.80	3 x 25 µg 3 x 25 ul

Histone H3K36 Methylation Antibody Panel Pack
C10008	EpiGentek	EUR 754.26 EUR 470.80	3 x 25 µg 3 x 25 ul

Histone H3K79 Methylation Antibody Panel Pack
C10009	EpiGentek	EUR 754.26 EUR 470.80	3 x 25 µg 3 x 25 ul

Histone H3 Acetylation Antibody Panel Pack I
C10010	EpiGentek	EUR 928.26 EUR 588.50	4 x 25 µg 4 x 25 ul

Histone H3 Acetylation Antibody Panel Pack II
C10011	EpiGentek	EUR 928.26 EUR 588.50	4 x 25 µg 4 x 25 ul

Histone H4K20 Methylation Antibody Panel Pack
C10012	EpiGentek	EUR 754.26 EUR 470.80	3 x 25 µg 3 x 25 ul

Histone H4 Acetylation Antibody Panel Pack
C10013	EpiGentek	EUR 754.26 EUR 470.80	4 x 25 µg 4 x 25 ul

Histone H3 Phosphorylation Antibody Panel Pack
C10014	EpiGentek	EUR 754.26 EUR 470.80	3 x 25 µg 3 x 25 ul

Histone H3R2 Methylation Antibody Panel Pack
C10015	EpiGentek	EUR 754.26 EUR 470.80	3 x 25 µg 3 x 25 ul

Histone H3R8 Methylation Antibody Panel Pack
C10016	EpiGentek	EUR 754.26 EUR 470.80	3 x 25 µg 3 x 25 ul

Histone H3R17 Methylation Antibody Panel Pack
C10017	EpiGentek	EUR 754.26 EUR 470.80	3 x 25 µg 3 x 25 ul

Histone H3R26 Methylation Antibody Panel Pack
C10018	EpiGentek	EUR 754.26 EUR 470.80	3 x 25 µg 3 x 25 ul

Histone H4R3 Methylation Antibody Panel Pack
C10019	EpiGentek	EUR 754.26 EUR 470.80	3 x 25 µg 3 x 25 ul

DNMT3A Protein
E11000	EpiGentek	EUR 971.76 EUR 618.20	10 µg 10 ul

TET1 Protein (Active)
E12002	EpiGentek	EUR 387.12 EUR 225.50	10 µg 10 ul

DNMT3B Protein
E14000	EpiGentek	EUR 971.76 EUR 618.20	10 µg 10 ul

DNMT1 Protein
E15000	EpiGentek	EUR 971.76 EUR 618.20	10 µg 10 ul

HDAC1 Protein
E24002	EpiGentek	EUR 968.28 EUR 616.00	50 µg 50 ul

HDAC10 Protein
E24003	EpiGentek	EUR 968.28 EUR 616.00	50 µg 50 ul

HDAC11 Protein
E24004	EpiGentek	EUR 968.28 EUR 616.00	50 µg 50 ul

HDAC2 Protein
E24005	EpiGentek	EUR 968.28 EUR 616.00	50 µg 50 ul

HDAC3 Protein
E24006	EpiGentek	EUR 968.28 EUR 616.00	50 µg 50 ul

HDAC4 Protein
E24007	EpiGentek	EUR 968.28 EUR 616.00	10 µg 10 ul

HDAC5 Protein
E24008	EpiGentek	EUR 968.28 EUR 616.00	10 µg 10 ul

HDAC6 Protein
E24009	EpiGentek	EUR 968.28 EUR 616.00	50 µg 50 ul

HDAC7 Protein
E24010	EpiGentek	EUR 968.28 EUR 616.00	10 µg 10 ul

HDAC8 Protein
E24011	EpiGentek	EUR 968.28 EUR 616.00	50 µg 50 ul

HDAC9 Protein
E24012	EpiGentek	EUR 968.28 EUR 616.00	10 µg 10 ul

H3F3A Protein
E35003	EpiGentek	EUR 174.84 EUR 78.10	50 µg 50 ul

H4 Protein
E35005	EpiGentek	EUR 174.84 EUR 78.10	50 µg 50 ul

SOD1 Protein
E70000	EpiGentek	EUR 599.40 EUR 365.20	25 µg 25 ul

Goat Anti-Rabbit Secondary Antibody, Biotin Conjugated
A12001	EpiGentek	EUR 232.26 EUR 117.70	350 µg 350 ug

Goat Anti-Rat Secondary Antibody, Biotin Conjugated
A12002	EpiGentek	EUR 232.26 EUR 117.70	350 µg 350 ug

HRP-Goat Anti-Mouse Secondary Antibody
A12003	EpiGentek	EUR 232.26 EUR 117.70	350 µg 350 ug

HRP-Goat Anti-Rabbit Secondary Antibody
A12004	EpiGentek	EUR 232.26 EUR 117.70	350 µg 350 ug

EpiMag HT (96-Well) Magnetic Separator
Q10002	EpiGentek	EUR 416.70 EUR 258.50	1/Pack 1/Pack

EpiMag 96-Well Microplate (5/pack)
Q10003	EpiGentek	EUR 136.56 EUR 52.80	5/pack 5/pack

Human Genomic DNA
X11000	EpiGentek	Ask for price EUR 235.40	0.2 ml 0.2 ml

Human Brain Genomic DNA
X11001	EpiGentek	Ask for price EUR 77.00	10 µg 10 ul

DNA Methylation Antibody Panel Pack I
C20000	EpiGentek	EUR 458.46 EUR 270.60	each 2 x 25 ul

Contactin-1, FC Chimera
PR15072	Neuromics	100 ug	EUR 568.8

TIE-1 Fc Chimera
PR27153	Neuromics	2 ug	EUR 229.2

Plastic Columns Frits
FC-100	ABTBeads	100/pk	EUR 146.4

Plastic Columns Frits
FC-50	ABTBeads	50/pk	EUR 99.6

FGFR4 Fibroblast Growth Factor Receptor 4 Fc Chimera Human Recombinant Protein
PROTP22455-1	BosterBio	Regular: 10ug	EUR 380.4
Description: Soluble FGFR-4a (IIIc) Fc Chimera Human Recombinant fused with Xa cleavage site with the Fc part of human IgG1 produced in baculovirus is a heterodimeric, glycosylated, Polypeptide chain and having a molecular mass of 170 kDa. ;The FGFR4 is purified by proprietary chromatographic techniques.

Neurogenic Locus Notch Homolog Protein 1 (NOTCH1) Antibody
20-abx121449	Abbexa	EUR 360.00 EUR 526.80 EUR 226.80	100 ul 200 ul 30 ul

Neurogenic Locus Notch Homolog Protein 1 (NOTCH1) Antibody
20-abx123022	Abbexa	EUR 493.20 EUR 710.40 EUR 218.40 EUR 376.80	100 ul 200 ul 20 ul 50 ul

Neurogenic Locus Notch Homolog Protein 1 (NOTCH1) Antibody
20-abx125373	Abbexa	EUR 710.40 EUR 1028.40 EUR 493.20	100 ul 200 ul 50 ul

Neurogenic Locus Notch Homolog Protein 1 (NOTCH1) Antibody
abx125424-50ul	Abbexa	50 ul	EUR 493.2

Neurogenic Locus Notch Homolog Protein 1 (NOTCH1) Antibody
20-abx114155	Abbexa	EUR 878.40 EUR 477.60	150 ul 50 ul

Neurogenic Locus Notch Homolog Protein 1 (NOTCH1) Antibody
20-abx001906	Abbexa	EUR 710.40 EUR 1028.40 EUR 493.20	100 ul 200 ul 50 ul

Neurogenic Locus Notch Homolog Protein 1 (NOTCH1) Antibody
abx037878-100ug	Abbexa	100 ug	EUR 469.2

Neurogenic Locus Notch Homolog Protein 1 (NOTCH1) Antibody
abx038468-100ug	Abbexa	100 ug	EUR 469.2

Methods, akin to telegenetics, promotion of evidence-based tips, point-of-care threat evaluation instruments, tailor-made schooling in genetics-related matters, and different system-level methods, will facilitate higher genetics and first care integration, which in flip, might enhance genetic service supply to sufferers residing in underserved communities.