Substance Use Disorders (SUD) are chronic relapsing medical conditions characterized by compulsive substance seeking and use. They constitute a substantial disease burden globally. Labeling of persons with SUD has created barriers to treatment but there are effective management strategies. The dental profession has embraced reforms designed to address the SUD epidemic by promoting continuing education for practitioners and initiating curriculum changes in dental schools. Screening, Brief Intervention and Referral to Treatment (SBIRT) is an evidence-based model for managing patients with SUD.
The use of a formative 1-station Objective Structured Clinical Examination (OSCE) for learning and assessment in SBIRT, operationalized with the MD3 rating scale is presented in this study. In 3 years of implementation, the SBIRT OSCE successfully integrated into the curriculum of the College of Dental Medicine, Columbia University. Mean score of total adherent behaviours was 11.80 (SD = 4.23) (range: 2 – 24) and Cronbach’s coefficient alpha for across-items reliability in adherent behaviours was 0.66. Adherent behaviours correlated with the global ratings (r = 0.66). Mean of global rating scores were 2.90 (SD = 1.01) for collaboration and 2.97 (SD = 1.00) for empathy and the global rating scores correlated with each other (r = 0.85). Histograms of global rating scores resembled normal distribution. The 1-station OSCE is a good model for learning about SBIRT. Psychometric analysis was useful in understanding the underlying construct of the MD3 rating scale and supported its reliability, validity and utility in dental education.
Delivering online alternatives to the anatomy laboratory: early experience during the COVID-19 pandemic
Social distancing measures due to the COVID-19 pandemic will make anatomy dissecting room practicals difficult, if not impossible to run at some institutions in the upcoming academic year. The learning community that exists within physical anatomy practicals needs to be moved online. Virtual replacement of visuo-spatial and social elements of learning anatomy pose particular challenges to educators.
Our department has trialled Blackboard Collaborate, an online communication platform in conjunction with Visible Body, a 3D anatomical modelling program. We have delivered 266 hours of synchronous small group teaching to medical and physician associate students. We describe this approach and discuss the relevance of distance learning pedagogy to the design of new online anatomy teaching and development of online learning communities. This article is protected by copyright. All rights reserved.
Attitudes of key professionals towards people with intellectual disabilities and their inclusion in society: A qualitative study in an Indonesian context
This study aimed to explore key professionals’ attitudes towards people with intellectual disability (ID) and inclusion of said people in the community. Eighteen participants from three professional groups, comprising health practitioners (medical doctors, psychologists), mainstream/special education teachers, and religious leaders (Islam, Catholicism, Protestantism, Hinduism, and Buddhism) were recruited. Semistructured interviews, aided by two vignettes depicting mild and severe ID, were conducted.
Thematic analysis was used to analyse the data. Seven themes were identified exploring: perceived causes; use of terminology; attitudes towards people with ID; attitudes towards inclusion, religion and ID; family-centric support; and challenges faced by people with ID in a wider context. Perceived capabilities of persons with ID were found to influence attitudes towards people with ID and their inclusion. Availability and accessibility of good quality services were also found to influence attitudes towards the inclusion of people with ID. Cultural factors related to attitudes towards ID are discussed.
The Great Gamble? A Mixed-Methods Study of Factors In˜fluencing Medical Students in Specialty Choice
Career planning remains relatively unexplored as a domain of medical education. Our aim was to explore the career planning journey undertaken by medical students. Results Approximately one third of participants had decided their future specialty. Important factors in career choice were ‘interest in specific [specialty] aspects,’ ‘work-life balance,’ ‘personality type’ of others in the specialty, an enjoyable experience on rotation and role models. Negative influential factors included poor conduct of doctors encountered and negative portrayals of specialities by practicing doctors. Conclusion The undergraduate and early postgraduate periods are formative times in career planning for junior doctors. Students and interns/FY1s are strongly influenced by doctors in the clinical setting, and clinicians should be aware of this power to exert both positive and negative influence.

Dawning of Onco-Cardiology
Recent progress in cancer therapy has decreased all-cancer mortality, but cardiovascular adverse events owing to chemotherapy and radiotherapy have greater impact on clinical outcome and quality of life in cancer patients and survivors. There are a wide variety of cardiovascular adverse events related to cancer therapy, and the opportunities requiring specialized care by cardiovascular experts are increasing in clinical practice. Under such circumstances, onco-cardiology is becoming very important as a new discipline and attracting much attention in Japan.
Rat IgG (Fc)-Biotin Conjuagte (isotype control), purified |
20005-1-FC-B |
Alpha Diagnostics |
0.1 mg |
EUR 270 |
Rat IgG (Fc)-FITC Conjuagte (isotype control), purified |
20005-1-FC-F |
Alpha Diagnostics |
0.1 mg |
EUR 270 |
Rat IgG (Fc)-HRP Conjuagte (isotype control), purified |
20005-1-FC-HP |
Alpha Diagnostics |
0.1 mg |
EUR 270 |
Human IgG (Fc) fragment, purified (>95%, low endotoxin) |
20007-1-FC-LE |
Alpha Diagnostics |
100 ul |
EUR 270 |
SARS-CoV-2 Spike S1 RBD Protein, Mouse Fc-fusion |
E80026 |
EpiGentek |
|
|
Sheep IgG-Fc ELISA Kit, 96 tests, Quantitative |
7615-Fc |
Alpha Diagnostics |
1 kit |
EUR 854.4 |
Horse IgG-Fc ELISA Kit, 96 tests, Quantitative |
7715-Fc |
Alpha Diagnostics |
1 kit |
EUR 854.4 |
Recombinant Dkk-1 Protein (Thr 32-His 266) [Fc] [Avi] |
VAng-1452Lsx-200g |
Creative Biolabs |
200 µg |
EUR 4612.8 |
Description: Biotinylated Human Dkk-1, Fc tag and Avi tag, is expressed in HEK 293 cells. (Uniprot ID: O94907-1) |
Recombinant Dkk-1 Protein (Thr 32-His 266) [Fc] [Avi] |
VAng-1452Lsx-25g |
Creative Biolabs |
25 µg |
EUR 1215.6 |
Description: Biotinylated Human Dkk-1, Fc tag and Avi tag, is expressed in HEK 293 cells. (Uniprot ID: O94907-1) |
Dog IgG (Fc) fragment (isotype control, non-immune), purified |
20016-FC |
Alpha Diagnostics |
0.5 mg |
EUR 300 |
Human IgG Fc-Biotin conjugate (isotype control, non-immune), purified |
20007-1-Fc-B |
Alpha Diagnostics |
0.1 mg |
EUR 196.8 |
Human IgG Fc-FITC conjugate (isotype control, non-immune), purified |
20007-1-Fc-F |
Alpha Diagnostics |
0.1 mg |
EUR 196.8 |
Human IgG Fc-HRP conjugate (isotype control, non-immune), purified |
20007-1-Fc-HP |
Alpha Diagnostics |
0.1 mg |
EUR 196.8 |
SARS-CoV-2 Spike S1 (13-665) Protein, Fc Fusion, Avi-tag |
E80020 |
EpiGentek |
|
|
SARS-CoV-2 Spike S1 (16-685) Protein, Fc Fusion, Avi-tag |
E80022 |
EpiGentek |
|
|
SARS-CoV-2 Spike S1 RBD Protein, Human Fc-Fusion, Avi-Tag |
E80025 |
EpiGentek |
|
|
DKK-1 Recombinant Protein |
40-225-0002mg |
ProSci |
0.002 mg |
EUR 311.1 |
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues. |
DKK-1 Recombinant Protein |
40-225-001mg |
ProSci |
0.01 mg |
EUR 437.1 |
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues. |
Dkk-1 Polyclonal Antibody |
41928-100ul |
SAB |
100ul |
EUR 302.4 |
Dkk-1 Polyclonal Antibody |
41928-50ul |
SAB |
50ul |
EUR 224.4 |
Dkk-1 Polyclonal Antibody |
ABP53293-003ml |
Abbkine |
0.03ml |
EUR 189.6 |
|
Description: A polyclonal antibody for detection of Dkk-1 from Human, Mouse, Rat. This Dkk-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Dkk-1 |
Dkk-1 Polyclonal Antibody |
ABP53293-01ml |
Abbkine |
0.1ml |
EUR 346.8 |
|
Description: A polyclonal antibody for detection of Dkk-1 from Human, Mouse, Rat. This Dkk-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Dkk-1 |
Dkk-1 Polyclonal Antibody |
ABP53293-02ml |
Abbkine |
0.2ml |
EUR 496.8 |
|
Description: A polyclonal antibody for detection of Dkk-1 from Human, Mouse, Rat. This Dkk-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Dkk-1 |
DKK 1 Recombinant Protein |
96-236 |
ProSci |
0.1 mg |
EUR 752.1 |
Description: Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway, binds to LRP6 with high affinity and prevents the Frizzled-Wnt-LRP6 complex formation in response to Wnts. DKK1 promotes LRP6 internalization and degradation when it forms a ternary complex with the cell surface receptor Kremen.DKK1 not olny functions as a head inducer during development, but also regulates joint remodeling and bone formation, which suggests roles for DKK1 in the pathogenesis of rheumatoid arthritis and multiple myeloma. More recently research reported, DKK1 impacts eye development from a defined developmental time point on, and is critical for lens separation from the surface ectoderm via β-catenin mediated Pdgfrα and E-cadherin expression. |
DKK 1 Recombinant Protein |
96-237 |
ProSci |
0.025 mg |
EUR 619.8 |
Description: Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway, binds to LRP6 with high affinity and prevents the Frizzled-Wnt-LRP6 complex formation in response to Wnts. DKK1 promotes LRP6 internalization and degradation when it forms a ternary complex with the cell surface receptor Kremen.DKK1 not olny functions as a head inducer during development, but also regulates joint remodeling and bone formation, which suggests roles for DKK1 in the pathogenesis of rheumatoid arthritis and multiple myeloma. More recently research reported, DKK1 impacts eye development from a defined developmental time point on, and is critical for lens separation from the surface ectoderm via β-catenin mediated Pdgfrα and E-cadherin expression. |
Dkk-1 Recombinant Protein |
96-861 |
ProSci |
0.1 mg |
EUR 651.3 |
Description: Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway, binds to LRP6 with high affinity and prevents the Frizzled-Wnt-LRP6 complex formation in response to Wnts. DKK1 promotes LRP6 internalization and degradation when it forms a ternary complex with the cell surface receptor Kremen.DKK1 not olny functions as a head inducer during development, but also regulates joint remodeling and bone formation, which suggests roles for DKK1 in the pathogenesis of rheumatoid arthritis and multiple myeloma. More recently research reported, DKK1 impacts eye development from a defined developmental time point on, and is critical for lens separation from the surface ectoderm via beta-catenin mediated Pdgfralpha and E-cadherin expression. |
Dkk-1 Recombinant Protein |
96-990 |
ProSci |
0.05 mg |
EUR 714.3 |
Description: Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway, binds to LRP6 with high affinity and prevents the Frizzled-Wnt-LRP6 complex formation in response to Wnts. DKK1 promotes LRP6 internalization and degradation when it forms a ternary complex with the cell surface receptor Kremen.DKK1 not olny functions as a head inducer during development, but also regulates joint remodeling and bone formation, which suggests roles for DKK1 in the pathogenesis of rheumatoid arthritis and multiple myeloma. More recently research reported, DKK1 impacts eye development from a defined developmental time point on, and is critical for lens separation from the surface ectoderm via beta-catenin mediated Pdgfralpha and E-cadherin expression. |
Dkk-1 Polyclonal Antibody |
ES4292-100ul |
ELK Biotech |
100ul |
EUR 334.8 |
Description: A Rabbit Polyclonal antibody against Dkk-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
Dkk-1 Polyclonal Antibody |
ES4292-50ul |
ELK Biotech |
50ul |
EUR 248.4 |
Description: A Rabbit Polyclonal antibody against Dkk-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
Anti-Dkk-1 antibody |
STJ97257 |
St John's Laboratory |
200 µl |
EUR 236.4 |
Description: Rabbit polyclonal to Dkk-1. |
Anti-Dkk-1 antibody |
STJ98000 |
St John's Laboratory |
100 µl |
EUR 280.8 |
Description: Mouse monoclonal to Dkk-1. |
IGF-1-Fc |
E13-m003-1 |
EnoGene |
10μg |
EUR 349.2 |
Recombinant (HEK) Rabbit IgG (Fc) (101-323aa, 185Thr/Asn284Ser, ~33 kda, >95%, Low Endotoxin) |
20009-1-R-FC |
Alpha Diagnostics |
50 ug |
EUR 343.2 |
Goat IgG (fc)-Biotin conjugate (isotype control) |
20011-Fc-B |
Alpha Diagnostics |
100 ug |
EUR 196.8 |
Goat IgG (fc)-FITC conjugate (isotype control) |
20011-Fc-F |
Alpha Diagnostics |
100 ug |
EUR 196.8 |
Goat IgG (fc)-HRP conjugate (isotype control) |
20011-Fc-HP |
Alpha Diagnostics |
100 ug |
EUR 196.8 |
Human IgG (Fc) fragment-Biotin purified (>95%, low endotoxin) |
20007-1-FC-LE-B |
Alpha Diagnostics |
25 ug |
EUR 343.2 |
Dkk-1 Polyclonal Conjugated Antibody |
C41928 |
SAB |
100ul |
EUR 476.4 |
Human DKK-1 ELISA kit |
LF-EK50797 |
Abfrontier |
1×96T |
EUR 777.6 |
DKK-1 (HEK293-expressed), Human |
HY-P7155A |
MedChemExpress |
50ug |
EUR 1011.6 |
Recombinant Human DKK-1 Protein |
PROTO94907-3 |
BosterBio |
10ug |
EUR 380.4 |
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues. |
Recombinant Mouse Dkk-1 Protein |
RP01062 |
Abclonal |
5 μg |
EUR 219.6 |
FC 131 |
B7647-1 |
ApexBio |
1 mg |
EUR 224.4 |
Dog IgG (Fc) fragment (isotype control, non-immune), purified |
20016-3-FC |
Alpha Diagnostics |
0.5 mg |
EUR 300 |
PD-1 (CD279), Fc fusion (Human) |
71106-1 |
BPS Bioscience |
100 µg |
EUR 345 |
Description: Human secreted programmed cell death 1 (PD-1)-Fc fusion protein, also known as, PDCD1, SLEB2, CD279 and HPD-L, GenBank Accession No. NM_005018, a.a 25-167, fused at the C-terminus to the Fc portion of human IgG1, expressed in a HEK293 cell expression system. MW = 42.6 kDa. This protein runs at a higher M.W. by SDS-PAGE due to glycosylation. |
PD-1, Fc Fusion, PE-labeled |
71243-1 |
BPS Bioscience |
50 µg |
EUR 455 |
Description: Human secreted programmed cell death 1 (PD-1)-Fc fusion protein, also known as, PDCD1, SLEB2, CD279 and HPD-L, GenBank Accession No. NM_005018, a.a 25-167, fused at the Cterminus to the Fc portion of human IgG1, expressed in a HEK293 cell expression system. This protein runs at a higher M.W. by SDS-PAGE due to glycosylation. The protein was randomly labeled with RPE on accessible lysine residues. |
Dkk-3 antibody |
22898-100ul |
SAB |
100ul |
EUR 468 |
Dog IgG Fc-Biotin Conjugate (isotype control, non-immune), purified |
20016-FC-B |
Alpha Diagnostics |
0.1 mg |
EUR 270 |
Dog IgG Fc-FITC Conjugate (isotype control, non-immune), purified |
20016-FC-F |
Alpha Diagnostics |
0.1 mg |
EUR 270 |
Dog IgG Fc-HRP Conjugate (isotype control, non-immune), purified |
20016-FC-HP |
Alpha Diagnostics |
0.1 mg |
EUR 270 |
OPG-Fc Osteoprotegerin Human Recombinant Protein /Fc Chimera |
PROTO00300-1 |
BosterBio |
Regular: 50ug |
EUR 380.4 |
Description: Recombinant OPG produced in yeast contains 2x412 amino acid residues, including 180 residues from mature OPG (a.a 22-201) and 232 residues from the Fc protein of human IgG1, and has a calculated molecular mass of 109.6kDa.  |
B7-1 (CD80), Fc fusion, Biotin-labeled |
71114-1 |
BPS Bioscience |
25 µg |
EUR 295 |
Description: Human secreted B7-1-Fc fusion protein, also known as CD80, with C-terminal Avi-tag™. GenBank Accession No. NM_005191, a.a 35-242 expressed in a HEK293 cell expression system and enzymatically biotin-labeled using Avi-tag™ technology. MW = 52.5 kDa (monomer). This protein runs at a higher M.W. by SDS-PAGE due to glycosylation. |
PD-1 (I126A), Fc fusion, Biotin-labeled |
71238-1 |
BPS Bioscience |
25 µg |
EUR 295 |
Description: Human secreted Programmed Cell Death 1_x000D_(PD-1)-Fc fusion protein, also known as_x000D_CD279, PDCD1, and SLEB2, GenBank_x000D_Accession No. NM_014143, amino acids_x000D_25-167 with an I126A mutation, fused at the_x000D_C-terminus with the Fc portion of human_x000D_IgG1, and C-terminal AviTag™, expressed_x000D_in a HEK293 cell expression system and_x000D_enzymatically biotin-labeled using AviTag™_x000D_technology. MW = 44.5 kDa. This protein_x000D_runs at a higher MW by SDS-PAGE due to_x000D_glycosylation. |
PD-1 (K78A), Fc fusion, Biotin-labeled |
71244-1 |
BPS Bioscience |
25 µg |
EUR 295 |
Description: Human secreted Programmed Cell Death 1_x000D_(PD-1)-Fc fusion protein, also known as_x000D_CD279, PDCD1, and SLEB2, GenBank_x000D_Accession No. NM_014143, a.a. 25-167_x000D_with a K78A mutation, fused at the Cterminus_x000D_with the Fc portion of human IgG1,_x000D_and C-terminal AviTag™, expressed in a_x000D_HEK293 cell expression system and_x000D_enzymatically biotin-labeled using AviTag™_x000D_technology. MW = 44.5 kDa. This protein_x000D_runs at a higher MW by SDS-PAGE due to_x000D_glycosylation. |
PD-1 (I134A), Fc fusion, Biotin-labeled |
71245-1 |
BPS Bioscience |
25 µg |
EUR 295 |
Description: Human secreted Programmed Cell Death 1_x000D_(PD-1)-Fc fusion protein, also known as_x000D_CD279, PDCD1, and SLEB2, GenBank_x000D_Accession No. NM_014143, a.a. 25-167_x000D_with an I134A mutation, fused at the Cterminus_x000D_with the Fc portion of human IgG1,_x000D_and C-terminal AviTag™, expressed in a_x000D_HEK293 cell expression system and_x000D_enzymatically biotin-labeled using AviTag™_x000D_technology. MW = 44.5 kDa. This protein_x000D_runs at a higher MW by SDS-PAGE due to_x000D_glycosylation. |
PD-1 (P130A), Fc fusion, Biotin-labeled |
71246-1 |
BPS Bioscience |
25 µg |
EUR 295 |
Description: Human secreted Programmed Cell Death 1_x000D_(PD-1)-Fc fusion protein, also known as_x000D_CD279, PDCD1, and SLEB2, GenBank_x000D_Accession No. NM_014143, a.a. 25-167_x000D_with an P130A mutation, fused at the Cterminus_x000D_with the Fc portion of human IgG1,_x000D_and C-terminal AviTag™, expressed in a_x000D_HEK293 cell expression system and_x000D_enzymatically biotin-labeled using AviTag™_x000D_technology. MW = 44.5 kDa. This protein_x000D_runs at a higher MW by SDS-PAGE due to_x000D_glycosylation. |
PD-1 (E136A), Fc fusion, Biotin-labeled |
71247-1 |
BPS Bioscience |
25 µg |
EUR 295 |
Description: Human secreted Programmed Cell Death 1_x000D_(PD-1)-Fc fusion protein, also known as_x000D_CD279, PDCD1, and SLEB2, GenBank_x000D_Accession No. NM_014143, a.a. 25-167_x000D_with an E136A mutation, fused at the Cterminus_x000D_with the Fc portion of human IgG1,_x000D_and C-terminal AviTag™, expressed in a_x000D_HEK293 cell expression system and_x000D_enzymatically biotin-labeled using AviTag™_x000D_technology. MW = 44.5 kDa. This protein_x000D_runs at a higher MW by SDS-PAGE due to_x000D_glycosylation. |
PD-1 (L128A), Fc fusion, Biotin-labeled |
71248-1 |
BPS Bioscience |
25 µg |
EUR 295 |
Description: Human secreted Programmed Cell Death 1_x000D_(PD-1)-Fc fusion protein, also known as_x000D_CD279, PDCD1, and SLEB2, GenBank_x000D_Accession No. NM_014143, a.a. 25-167_x000D_with an L128A mutation, fused at the Cterminus_x000D_with the Fc portion of human IgG1,_x000D_and C-terminal AviTag™, expressed in a_x000D_HEK293 cell expression system and_x000D_enzymatically biotin-labeled using AviTag™_x000D_technology. MW = 44.5 kDa. This protein_x000D_runs at a higher MW by SDS-PAGE due to_x000D_glycosylation. |
Human DKK-1 PicoKine ELISA Kit |
EK0867 |
BosterBio |
96 wells |
EUR 510 |
Description: For quantitative detection of human DKK1 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA). |
ELISA kit for Human DKK-1 |
EK5390 |
SAB |
96 tests |
EUR 663.6 |
Description: Enzyme-linked immunosorbent assay kit for quantification of Human DKK-1 in samples from serum, plasma, tissue homogenates and other biological fluids. |
ELISA kit for Rat DKK-1 |
EK5668 |
SAB |
96 tests |
EUR 663.6 |
Description: Enzyme-linked immunosorbent assay kit for quantification of Rat DKK-1 in samples from serum, plasma, tissue homogenates and other biological fluids. |
Human CellExp? DKK-1, Human Recombinant |
7132-10 |
Biovision |
each |
EUR 333.6 |
Human CellExp? DKK-1, Human Recombinant |
7132-50 |
Biovision |
each |
EUR 1358.4 |
Recombinant (HEK) Human IgG3-Fc (99-377aa, His-tag, >95%, low endotoxin) |
20007-G3-FC |
Alpha Diagnostics |
50 ug |
EUR 343.2 |
SCF-Fc |
E13-m004-1 |
EnoGene |
10μg |
EUR 411.6 |
PD-1 (CD279), Fc fusion, Biotin-labeled (Human) |
71109-1 |
BPS Bioscience |
25 µg |
EUR 400 |
Description: Human secreted programmed cell death 1 (PD-1)-Fc fusion protein, also known as, PDCD1, SLEB2, CD279 and HPD-L, GenBank Accession No. NM_005018, a.a 25-167, fused at the C-terminus to the Fc portion of human IgG1, with C-terminal Avitag ™ expressed in a HEK293 cell expression system and enzymatically biotinlabeled using Avi-tag™ technology. MW = 44.5 kDa. This protein runs at a higher M.W. by SDS-PAGE due to glycosylation. |
Recombinant Human Dickkopf-Related Protein 2/DKK-2 (N-Fc, C-6His) |
CC49-10ug |
Novoprotein |
10ug |
EUR 187.2 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.2. |
Recombinant Human Dickkopf-Related Protein 2/DKK-2 (N-Fc, C-6His) |
CC49-1mg |
Novoprotein |
1mg |
EUR 2739.6 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.2. |
Recombinant Human Dickkopf-Related Protein 2/DKK-2 (N-Fc, C-6His) |
CC49-500ug |
Novoprotein |
500ug |
EUR 1935.6 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.2. |
Recombinant Human Dickkopf-Related Protein 2/DKK-2 (N-Fc, C-6His) |
CC49-50ug |
Novoprotein |
50ug |
EUR 442.8 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.2. |
DKK-2 Recombinant Protein |
40-651 |
ProSci |
2 ug |
EUR 311.1 |
Description: The dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 - 4, along with the distantly-related DKK family member DKK-11 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains. Playing an important regulatory role in vertebrate development through localized inhibition of Wnt-regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt/β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. DKK-2 has been shown to both inhibit and enhance canonical Wnt signaling; enhancing Wnt signaling through direct high-affinity binding of DKK-2 to LRP6 during LRP6 overexpression, while inhibiting Wnt signaling and promoting LRP6 internalization through the formation of a ternary complex between DKK-2, LRP6, and Kremen-2. Recombinant Human DKK-2 expressed in CHO cells is a glycoprotein that has a calculated molecular weight of 25.8 kDa and contains 234 amino acid residues. Due to glycosylation, human DKK-2 migrates at an apparent molecular weight of approximately 31-36 kDa by SDS-PAGE analysis under non-reducing conditions. |
DKK-3 Recombinant Protein |
40-652 |
ProSci |
2 ug |
EUR 311.1 |
Description: The dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 - 4, along with the distantly-related DKK family member DKK-L1 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains. Playing an important regulatory role in vertebrate development through localized inhibition of Wnt-regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt/β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. DKK-3 has been shown to potentiate, rather than inhibit, Wnt signaling through interactions with the high-affinity, transmembrane co-receptors Kremen-1 (Krm1) and Kremen-2 (Krm2). Recombinant Human DKK-3 expressed in CHO cells is a glycoprotein that has a calculated molecular weight of 36.3 kDa and contains 329 amino acid residues. Due to glycosylation, Human DKK-3 migrates at an apparent molecular weight of approximately 39-49 kDa by SDS-PAGE analysis under non-reducing conditions. |
Dkk-3 Polyclonal Antibody |
ABP54542-003ml |
Abbkine |
0.03ml |
EUR 189.6 |
|
Description: A polyclonal antibody for detection of Dkk-3 from Human, Mouse. This Dkk-3 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Dkk-3 at AA rangle: 80-160 |
Dkk-3 Polyclonal Antibody |
ABP54542-01ml |
Abbkine |
0.1ml |
EUR 346.8 |
|
Description: A polyclonal antibody for detection of Dkk-3 from Human, Mouse. This Dkk-3 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Dkk-3 at AA rangle: 80-160 |
Dkk-3 Polyclonal Antibody |
ABP54542-02ml |
Abbkine |
0.2ml |
EUR 496.8 |
|
Description: A polyclonal antibody for detection of Dkk-3 from Human, Mouse. This Dkk-3 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Dkk-3 at AA rangle: 80-160 |
DKK 3 Recombinant Protein |
96-239 |
ProSci |
0.2 mg |
EUR 821.4 |
Description: Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK3 has been proposed as tumour suppressor gene and a marker for tumour blood vessels. DKK3 is the only DKK family member abundantly expressed in normal lung, but silenced by promoter hypermethylation in a large fraction of lung cancer cell lines and lung tumors. Downregulation of DKK3 was correlated with tumor progression and expression of nuclear beta-catenin in lung tumors. Ectopic expression of DKK3 in lung cancer cells with DKK3 hypermethylation induced apoptosis and inhibited TCF-4 activity as well as nuclear accumulation of beta-catenin and expression of TCF-4 targets c-Myc and cyclin D1. DKK3 modulates FGF and Activin/Nodal signaling to regulate mesoderm induction during early Xenopus development, was reported. |
Dkk-3 Recombinant Protein |
96-991 |
ProSci |
0.05 mg |
EUR 651.3 |
Description: Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK3 has been proposed as tumour suppressor gene and a marker for tumour blood vessels. DKK3 is the only DKK family member abundantly expressed in normal lung, but silenced by promoter hypermethylation in a large fraction of lung cancer cell lines and lung tumors. Downregulation of DKK3 was correlated with tumor progression and expression of nuclear beta-catenin in lung tumors. Ectopic expression of DKK3 in lung cancer cells with DKK3 hypermethylation induced apoptosis and inhibited TCF-4 activity as well as nuclear accumulation of beta-catenin and expression of TCF-4 targets c-Myc and cyclin D1. DKK3 modulates FGF and Activin/Nodal signaling to regulate mesoderm induction during early Xenopus development, was reported. |
Dkk-3 Polyclonal Antibody |
ES5541-100ul |
ELK Biotech |
100ul |
EUR 334.8 |
Description: A Rabbit Polyclonal antibody against Dkk-3 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA |
Dkk-3 Polyclonal Antibody |
ES5541-50ul |
ELK Biotech |
50ul |
EUR 248.4 |
Description: A Rabbit Polyclonal antibody against Dkk-3 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA |
Anti-Dkk-3 antibody |
STJ92720 |
St John's Laboratory |
200 µl |
EUR 236.4 |
Description: Rabbit polyclonal to Dkk-3. |
Anti-Dkk-3 antibody |
STJ98001 |
St John's Laboratory |
100 µl |
EUR 280.8 |
Description: Mouse monoclonal to Dkk-3. |
Recombinant (HEK) Mouse IgG2a-Fc (98-330aa, ~34 kda, His-tag, >95%, low endotoxin) |
20102-102-FC |
Alpha Diagnostics |
50 ug |
EUR 343.2 |
Recombinant (HEK) Mouse IgG2b-Fc (97-335aa, ~37 kda, His-tag, >95%, low endotoxin) |
20102-103-FC |
Alpha Diagnostics |
50 ug |
EUR 343.2 |
Recombinant (HEK) Mouse IgG3-Fc (97-329aa, ~33 kda, His-tag, >95%, low endotoxin) |
20102-104-FC |
Alpha Diagnostics |
50 ug |
EUR 343.2 |
Recombinant (HEK) Human IgG1 Fc (103Cys/Ser, 99-330aa, His-tag, >95%, low endotoxin) |
20007-G1-FC |
Alpha Diagnostics |
50 ug |
EUR 343.2 |
Recombinant (HEK) Human IgG2-Fc (257Ser/Ala, 99-327aa, His-tag, >95%, low endotoxin) |
20007-G2-FC |
Alpha Diagnostics |
50 ug |
EUR 343.2 |
Recombinant (HEK) Human IgG4-Fc (108Ser/Pro, 99-327aa, His-tag, >95%, low endotoxin) |
20007-G4-FC |
Alpha Diagnostics |
50 ug |
EUR 343.2 |
ACE2, Fc Fusion (Monkey) |
100701-1 |
BPS Bioscience |
50 µg |
EUR 490 |
Description: Rhesus monkey angiotensin I converting enzyme 2 (ACE2), also known as ACEH, Genbank Accession No.: ACI04553.1, a.a. 18-739, fused at the C-terminus of the Fc portion of human IgG1, expressed in a HEK293 expression system, MW= 119 kDa. This protein runs at a higher MW due to glycosylation. |
IL6R, Fc-Fusion (IgG1) |
100916-1 |
BPS Bioscience |
100 µg |
EUR 320 |
Description: Human IL-6 Receptor, Genbank # NM_000565, a.a. 20-365 with C-terminal fusion to human IgG1 Fc region, expressed in HEK293 cells. MW = 65 kDa + glycans. |
CTLA4 (CD152), Fc fusion |
71149-1 |
BPS Bioscience |
100 µg |
EUR 150 |
Description: Human secreted CTLA4 , Fc fusion protein, also known as Cytotoxic T-lymphocyte-associated protein 4 and CD152. GenBank Accession No. NM_005214, a.a. 36-162 expressed in a HEK293 cell expression system. MW = 40.3 kDa (monomer). This protein runs at a higher MW by SDS-PAGE due to glycosylation. |
Recombinant Human CD47 Protein, His-Fc (IgG), Insect-10ug |
QP11336-HIS-Fc-10ug |
EnQuireBio |
10ug |
EUR 241.2 |
Human DKK-1 ELISA kit (4×96T) |
LF-EK50798 |
Abfrontier |
4×96T |
EUR 2641.2 |
Monkey (M. fascicularis) PD-1, Fc fusion, Biotin-labeled |
71235-1 |
BPS Bioscience |
25 µg |
EUR 295 |
Description: Secreted monkey Programmed Cell Death 1 (PD-1)-Fc fusion protein, also known as CD279, PDCD1, and SLEB2, GenBank Accession No. NM_005018, a.a. 25-167, fused at the C-terminus to the Fc portion of human IgG1 with a C-terminal Avitag™, expressed in a HEK293 cell expression system. MW = 42.6 kDa. Note: this protein runs at an apparent higher molecular weight due to glycosylation. Biotinylation was confirmed to be >90%. |
Recombinant (HEK) Mouse IgG1-Fc (98-321aa, 102Cys/Ser, ~32 kda, His-tag, >95%, low endotoxin) |
20102-101-FC |
Alpha Diagnostics |
50 |
EUR 343.2 |
SDF-1α-Fc |
E13-m001-1 |
EnoGene |
10μg |
EUR 349.2 |
VEGF-121-Fc |
E13-m005-1 |
EnoGene |
10μg |
EUR 411.6 |
VEGF-165-Fc |
E13-m006-1 |
EnoGene |
10μg |
EUR 411.6 |
IL-2-Fc |
E13-m007-1 |
EnoGene |
10μg |
EUR 372 |
PinPoint-FC attP Placement Vector |
PIN300A-1 |
SBI |
10ug |
EUR 933.6 |
|
CD24, Fc Fusion, Avi-tag |
100527-1 |
BPS Bioscience |
100 µg |
EUR 320 |
Description: Human secreted CD24, also known as Signal Transducer CD24, Small Cell Lung Carcinoma Cluster 4 Antigen and CD24A, GenBank Accession No. NM_013230, a.a. 27-59(end), fused at the C-terminus of the Fc portion of human IgG1, with C-terminal Avi-tag™, expressed in a HEK293 cell expression system. MW = 32 kDa. This protein runs at a higher MW by SDS-PAGE due to glycosylation. |
Siglec9, Fc Fusion, Avi-tag |
100558-1 |
BPS Bioscience |
100 µg |
EUR 320 |
Description: Human secreted Sialic Acid Binding Ig Like Lectin 9 (Siglec 9), also known as CD329, CDw329, FOAP-9, and OBBP-LIKE, GenBank Accession No. NM_014441.2, a.a. 18-348, fused at the C-terminus of the Fc portion of human IgG1, with C-terminal Avi-tag, expressed in a HEK293 cell expression system. MW = 66 kDa. This protein runs at a higher molecular weight due to glycosylation. |
CD5, Fc-Fusion, Avi-Tag |
101005-1 |
BPS Bioscience |
100 µg |
EUR 320 |
Description: Recombinant human CD5 encompassing amino acids 25-371. This protein is fused in C-terminal with the Fc fragment of human IgG1 (230 amino acids) followed by a C-terminal Avi-Tag™. The recombinant protein was affinity purified. HiP™ indicates a high purity protein (≥90% pure) and less than 10% aggregation as measured by gel filtration. |
GFRAL, Fc Fusion, Avi-Tag |
101012-1 |
BPS Bioscience |
100 µg |
EUR 320 |
Description: Recombinant human GFRAL (GDNF family receptor alpha like) encompassing amino acids 19-351 (end). This protein is fused in C-terminal with the Fc fragment of human IgG1 followed by a C-terminal Avi-Tag™. The recombinant protein was affinity purified. |
CD47, Fc fusion, Biotin-labeled |
71169-1 |
BPS Bioscience |
25 µg |
EUR 295 |
Description: Human CD47, also known as leukocyte surface antigen CD47, Rh-related antigen, integrin-associated protein (IAP), antigenic surface determinant protein OA3, and MER6. GenBank Accession No. NM_001777, a.a. 19-139 expressed in a HEK293 cell expression system, fused at the C-terminus to the Fc portion of human IgG1, and enzymatically biotin-labeled using Avi-tag™ technology. MW = 42.2 kDa. This protein runs at a higher MW by SDS-PAGE due to glycosylation. |
CD28H, Fc fusion, Biotin-labeled |
71239-1 |
BPS Bioscience |
25 µg |
EUR 295 |
Description: Human CD28 homolog (CD28H), also known as Transmembrane and immunoglobulin domain-containing protein 2 (TMIGD2) and immunoglobulin and prolinerich receptor 1 (IGPR-1). GenBank Accession No. NM_144615, a.a. 23-128 fused at the C-terminus to the Fc portion of human IgG1 followed by a C-terminal AviTag™ expressed in a HEK293 expression system. MW = 40 kDa. This protein is enzymatically biotinylated using Avi-tag™ technology. Biotinylation is confirmed to be greater than 90%. This protein runs at a higher MW by SDS-PAGE due to glycosylation. |
TIGIT, Fc fusion, Biotin-labeled |
71251-1 |
BPS Bioscience |
25 µg |
EUR 295 |
Description: Human T-cell immunoreceptor_x000D_with Ig and ITIM domains (TIGIT), also_x000D_known as V-set and immunoglobulin_x000D_domain-containing protein 9 (VSIG9), and_x000D_V-set and transmembrane domaincontaining_x000D_protein 3 (VSTM3), GenBank_x000D_Accession No. NM_173799, a.a. 22-141_x000D_fused to Fc region of human IgG1 and_x000D_enzymatically biotinylated using AviTag™_x000D_technology, expressed in a HEK293 cell_x000D_expression system. MW = 41.6 kDa_x000D_(monomer). This protein runs at a higher_x000D_MW by SDS-PAGE due to glycosylation. |
CD2, Fc fusion, Biotin-labeled |
71270-1 |
BPS Bioscience |
25 µg |
EUR 295 |
Description: Human secreted CD2-Fc fusion protein, also known as LFA-2, GenBank Accession No. NM_001767, a.a. 25-209, fused at the C-terminus to the Fc portion of human IgG1, with C-terminal Avi-tag, expressed in a HEK293 cell expression system and enzymatically biotin-labeled using Avi-tag technology. MW = 50 kDa (monomer). This protein runs at a higher M.W. by SDS-PAGE due to glycosylation. |
KIR2DL3, Fc fusion, Biotin-labeled |
71298-1 |
BPS Bioscience |
25 µg |
EUR 295 |
Description: Human KIR2DL3, also known as Killer cell immunoglobulin-like receptor 2DL3, KIR2DS5 and KIRCL23. GenBank Accession No. NM_015868. a.a. 22-245 fused at the C terminus to the Fc portion of human IgG1 followed by a C-termina Avi-tag™ and expressed in a HEK293 cell expression system. MW=53 kDa This protein is enzymatically biotinylated using Avi-Tag™ technology. Biotinylation is confirmed to be ≥90%. This protein runs at a higher MW due to glycosylation. |
B7-1 (Woodchuck), Fc-fusion (Human), Avi-Tag, Biotin-labeled |
100040-1 |
BPS Bioscience |
25 µg |
EUR 295 |
Description: Woodchuck B7-1, also known as CD80, with C-terminal Avi-Tag fused to the Fc-region of Human IgG1. a.a 30-237, expressed in a HEK293 cell expression system and enzymatically biotin-labeled using Avi-tag™ technology. MW = 52 kDa. This protein runs at a higher M.W. by SDS-PAGE due to glycosylation. |
The Japanese Onco-Cardiology Society was established in 2017, and continues integration of academic activities to solve challenging problems in this field. Interdisciplinary collaborations between cardiologists and oncologists will be further progressed in medical care, clinical and basic research, and education.