The Utility of a Formative One-Station Objective Structured Clinical Examination for Substance Use Disorders in a Dental Curriculum

Substance Use Disorders (SUD) are chronic relapsing medical conditions characterized by compulsive substance seeking and use. They constitute a substantial disease burden globally. Labeling of persons with SUD has created barriers to treatment but there are effective management strategies. The dental profession has embraced reforms designed to address the SUD epidemic by promoting continuing education for practitioners and initiating curriculum changes in dental schools. Screening, Brief Intervention and Referral to Treatment (SBIRT) is an evidence-based model for managing patients with SUD.

The use of a formative 1-station Objective Structured Clinical Examination (OSCE) for learning and assessment in SBIRT, operationalized with the MD3 rating scale is presented in this study. In 3 years of implementation, the SBIRT OSCE successfully integrated into the curriculum of the College of Dental Medicine, Columbia University. Mean score of total adherent behaviours was 11.80 (SD = 4.23) (range: 2 – 24) and Cronbach’s coefficient alpha for across-items reliability in adherent behaviours was 0.66. Adherent behaviours correlated with the global ratings (r = 0.66). Mean of global rating scores were 2.90 (SD = 1.01) for collaboration and 2.97 (SD = 1.00) for empathy and the global rating scores correlated with each other (r = 0.85). Histograms of global rating scores resembled normal distribution. The 1-station OSCE is a good model for learning about SBIRT. Psychometric analysis was useful in understanding the underlying construct of the MD3 rating scale and supported its reliability, validity and utility in dental education.

Delivering online alternatives to the anatomy laboratory: early experience during the COVID-19 pandemic

Social distancing measures due to the COVID-19 pandemic will make anatomy dissecting room practicals difficult, if not impossible to run at some institutions in the upcoming academic year. The learning community that exists within physical anatomy practicals needs to be moved online. Virtual replacement of visuo-spatial and social elements of learning anatomy pose particular challenges to educators.

Our department has trialled Blackboard Collaborate, an online communication platform in conjunction with Visible Body, a 3D anatomical modelling program. We have delivered 266 hours of synchronous small group teaching to medical and physician associate students. We describe this approach and discuss the relevance of distance learning pedagogy to the design of new online anatomy teaching and development of online learning communities. This article is protected by copyright. All rights reserved.

Attitudes of key professionals towards people with intellectual disabilities and their inclusion in society: A qualitative study in an Indonesian context

This study aimed to explore key professionals’ attitudes towards people with intellectual disability (ID) and inclusion of said people in the community. Eighteen participants from three professional groups, comprising health practitioners (medical doctors, psychologists), mainstream/special education teachers, and religious leaders (Islam, Catholicism, Protestantism, Hinduism, and Buddhism) were recruited. Semistructured interviews, aided by two vignettes depicting mild and severe ID, were conducted.

Thematic analysis was used to analyse the data. Seven themes were identified exploring: perceived causes; use of terminology; attitudes towards people with ID; attitudes towards inclusion, religion and ID; family-centric support; and challenges faced by people with ID in a wider context. Perceived capabilities of persons with ID were found to influence attitudes towards people with ID and their inclusion. Availability and accessibility of good quality services were also found to influence attitudes towards the inclusion of people with ID. Cultural factors related to attitudes towards ID are discussed.

The Great Gamble? A Mixed-Methods Study of Factors In˜fluencing Medical Students in Specialty Choice

Career planning remains relatively unexplored as a domain of medical education. Our aim was to explore the career planning journey undertaken by medical students. Results Approximately one third of participants had decided their future specialty. Important factors in career choice were ‘interest in specific [specialty] aspects,’ ‘work-life balance,’ ‘personality type’ of others in the specialty, an enjoyable experience on rotation and role models. Negative influential factors included poor conduct of doctors encountered and negative portrayals of specialities by practicing doctors. Conclusion The undergraduate and early postgraduate periods are formative times in career planning for junior doctors. Students and interns/FY1s are strongly influenced by doctors in the clinical setting, and clinicians should be aware of this power to exert both positive and negative influence.

Dawning of Onco-Cardiology

Recent progress in cancer therapy has decreased all-cancer mortality, but cardiovascular adverse events owing to chemotherapy and radiotherapy have greater impact on clinical outcome and quality of life in cancer patients and survivors. There are a wide variety of cardiovascular adverse events related to cancer therapy, and the opportunities requiring specialized care by cardiovascular experts are increasing in clinical practice. Under such circumstances, onco-cardiology is becoming very important as a new discipline and attracting much attention in Japan.

Dkk-1 Recombinant Protein
96-990	ProSci	0.05 mg	EUR 714.3
Description: Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway, binds to LRP6 with high affinity and prevents the Frizzled-Wnt-LRP6 complex formation in response to Wnts. DKK1 promotes LRP6 internalization and degradation when it forms a ternary complex with the cell surface receptor Kremen.DKK1 not olny functions as a head inducer during development, but also regulates joint remodeling and bone formation, which suggests roles for DKK1 in the pathogenesis of rheumatoid arthritis and multiple myeloma. More recently research reported, DKK1 impacts eye development from a defined developmental time point on, and is critical for lens separation from the surface ectoderm via beta-catenin mediated Pdgfralpha and E-cadherin expression.

Dkk-1 Polyclonal Antibody
ABP53293-003ml	Abbkine	0.03ml	EUR 189.6

Description: A polyclonal antibody for detection of Dkk-1 from Human, Mouse, Rat. This Dkk-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Dkk-1

Dkk-1 Polyclonal Antibody
ABP53293-01ml	Abbkine	0.1ml	EUR 346.8

Description: A polyclonal antibody for detection of Dkk-1 from Human, Mouse, Rat. This Dkk-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Dkk-1

Dkk-1 Polyclonal Antibody
ABP53293-02ml	Abbkine	0.2ml	EUR 496.8

Description: A polyclonal antibody for detection of Dkk-1 from Human, Mouse, Rat. This Dkk-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Dkk-1

DKK-1 Recombinant Protein
40-225-0002mg	ProSci	0.002 mg	EUR 311.1
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues.

DKK-1 Recombinant Protein
40-225-001mg	ProSci	0.01 mg	EUR 437.1
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues.

Dkk-1 Polyclonal Antibody
41928-100ul	SAB	100ul	EUR 302.4

Dkk-1 Polyclonal Antibody
41928-50ul	SAB	50ul	EUR 224.4

Dkk-1 Polyclonal Antibody
ES4292-100ul	ELK Biotech	100ul	EUR 334.8
Description: A Rabbit Polyclonal antibody against Dkk-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Dkk-1 Polyclonal Antibody
ES4292-50ul	ELK Biotech	50ul	EUR 248.4
Description: A Rabbit Polyclonal antibody against Dkk-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

DKK 1 Recombinant Protein
96-236	ProSci	0.1 mg	EUR 752.1
Description: Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway, binds to LRP6 with high affinity and prevents the Frizzled-Wnt-LRP6 complex formation in response to Wnts. DKK1 promotes LRP6 internalization and degradation when it forms a ternary complex with the cell surface receptor Kremen.DKK1 not olny functions as a head inducer during development, but also regulates joint remodeling and bone formation, which suggests roles for DKK1 in the pathogenesis of rheumatoid arthritis and multiple myeloma. More recently research reported, DKK1 impacts eye development from a defined developmental time point on, and is critical for lens separation from the surface ectoderm via β-catenin mediated Pdgfrα and E-cadherin expression.

DKK 1 Recombinant Protein
96-237	ProSci	0.025 mg	EUR 619.8
Description: Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway, binds to LRP6 with high affinity and prevents the Frizzled-Wnt-LRP6 complex formation in response to Wnts. DKK1 promotes LRP6 internalization and degradation when it forms a ternary complex with the cell surface receptor Kremen.DKK1 not olny functions as a head inducer during development, but also regulates joint remodeling and bone formation, which suggests roles for DKK1 in the pathogenesis of rheumatoid arthritis and multiple myeloma. More recently research reported, DKK1 impacts eye development from a defined developmental time point on, and is critical for lens separation from the surface ectoderm via β-catenin mediated Pdgfrα and E-cadherin expression.

Human DKK-1 ELISA kit
LF-EK50797	Abfrontier	1Ã—96T	EUR 777.6

DKK-1 ELISA KIT\|Human
EF000090	Lifescience Market	96 Tests	EUR 826.8

DKK-1 (CHO-expressed), Mouse
HY-P7154	MedChemExpress	50ug	EUR 914.4

DKK-1 (HEK293-expressed), Human
HY-P7155A	MedChemExpress	50ug	EUR 1011.6

Recombinant Human DKK-1 Protein
PROTO94907-3	BosterBio	10ug	EUR 380.4
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues.

Recombinant Mouse Dkk-1 Protein
RP01062	Abclonal	5 μg	EUR 219.6

Dkk-1 Polyclonal Conjugated Antibody
C41928	SAB	100ul	EUR 476.4

Dkk-3 antibody
22898-100ul	SAB	100ul	EUR 468

ELISA kit for Rat DKK-1
EK5668	SAB	96 tests	EUR 663.6
Description: Enzyme-linked immunosorbent assay kit for quantification of Rat DKK-1 in samples from serum, plasma, tissue homogenates and other biological fluids.

ELISA kit for Human DKK-1
EK5390	SAB	96 tests	EUR 663.6
Description: Enzyme-linked immunosorbent assay kit for quantification of Human DKK-1 in samples from serum, plasma, tissue homogenates and other biological fluids.

Human DKK-1 PicoKine ELISA Kit
EK0867	BosterBio	96 wells	EUR 510
Description: For quantitative detection of human DKK1 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Human CellExp? DKK-1, Human Recombinant
7132-10	Biovision	each	EUR 333.6

Human CellExp? DKK-1, Human Recombinant
7132-50	Biovision	each	EUR 1358.4

Dkk-3 Recombinant Protein
96-991	ProSci	0.05 mg	EUR 651.3
Description: Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK3 has been proposed as tumour suppressor gene and a marker for tumour blood vessels. DKK3 is the only DKK family member abundantly expressed in normal lung, but silenced by promoter hypermethylation in a large fraction of lung cancer cell lines and lung tumors. Downregulation of DKK3 was correlated with tumor progression and expression of nuclear beta-catenin in lung tumors. Ectopic expression of DKK3 in lung cancer cells with DKK3 hypermethylation induced apoptosis and inhibited TCF-4 activity as well as nuclear accumulation of beta-catenin and expression of TCF-4 targets c-Myc and cyclin D1. DKK3 modulates FGF and Activin/Nodal signaling to regulate mesoderm induction during early Xenopus development, was reported.

Dkk-3 Polyclonal Antibody
ABP54542-003ml	Abbkine	0.03ml	EUR 189.6

Description: A polyclonal antibody for detection of Dkk-3 from Human, Mouse. This Dkk-3 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Dkk-3 at AA rangle: 80-160

Dkk-3 Polyclonal Antibody
ABP54542-01ml	Abbkine	0.1ml	EUR 346.8

Description: A polyclonal antibody for detection of Dkk-3 from Human, Mouse. This Dkk-3 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Dkk-3 at AA rangle: 80-160

Dkk-3 Polyclonal Antibody
ABP54542-02ml	Abbkine	0.2ml	EUR 496.8

Description: A polyclonal antibody for detection of Dkk-3 from Human, Mouse. This Dkk-3 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Dkk-3 at AA rangle: 80-160

DKK-2 Recombinant Protein
40-651	ProSci	2 ug	EUR 311.1
Description: The dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 - 4, along with the distantly-related DKK family member DKK-11 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains. Playing an important regulatory role in vertebrate development through localized inhibition of Wnt-regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt/β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. DKK-2 has been shown to both inhibit and enhance canonical Wnt signaling; enhancing Wnt signaling through direct high-affinity binding of DKK-2 to LRP6 during LRP6 overexpression, while inhibiting Wnt signaling and promoting LRP6 internalization through the formation of a ternary complex between DKK-2, LRP6, and Kremen-2. Recombinant Human DKK-2 expressed in CHO cells is a glycoprotein that has a calculated molecular weight of 25.8 kDa and contains 234 amino acid residues. Due to glycosylation, human DKK-2 migrates at an apparent molecular weight of approximately 31-36 kDa by SDS-PAGE analysis under non-reducing conditions.

DKK-3 Recombinant Protein
40-652	ProSci	2 ug	EUR 311.1
Description: The dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 - 4, along with the distantly-related DKK family member DKK-L1 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains. Playing an important regulatory role in vertebrate development through localized inhibition of Wnt-regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt/β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. DKK-3 has been shown to potentiate, rather than inhibit, Wnt signaling through interactions with the high-affinity, transmembrane co-receptors Kremen-1 (Krm1) and Kremen-2 (Krm2). Recombinant Human DKK-3 expressed in CHO cells is a glycoprotein that has a calculated molecular weight of 36.3 kDa and contains 329 amino acid residues. Due to glycosylation, Human DKK-3 migrates at an apparent molecular weight of approximately 39-49 kDa by SDS-PAGE analysis under non-reducing conditions.

Dkk-3 Polyclonal Antibody
ES5541-100ul	ELK Biotech	100ul	EUR 334.8
Description: A Rabbit Polyclonal antibody against Dkk-3 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

Dkk-3 Polyclonal Antibody
ES5541-50ul	ELK Biotech	50ul	EUR 248.4
Description: A Rabbit Polyclonal antibody against Dkk-3 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

Human DKK-1 ELISA kit (4Ã—96T)
LF-EK50798	Abfrontier	4Ã—96T	EUR 2641.2

Nori® Human DKK-1 ELISA Kit
GR106268	Genorise Scientific	96-well	EUR 461

Nori® Mouse DKK-1 ELISA Kit
GR117408	Genorise Scientific	96-well	EUR 461

Nori® Mouse DKK-1 ELISA Kit
GR117418	Genorise Scientific	96-well	EUR 461

Recombinant Human Dickkopf-Related Protein 2/DKK-2 (N-Fc, C-6His)
CC49-10ug	Novoprotein	10ug	EUR 187.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.2.

Recombinant Human Dickkopf-Related Protein 2/DKK-2 (N-Fc, C-6His)
CC49-1mg	Novoprotein	1mg	EUR 2739.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.2.

Recombinant Human Dickkopf-Related Protein 2/DKK-2 (N-Fc, C-6His)
CC49-500ug	Novoprotein	500ug	EUR 1935.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.2.

Recombinant Human Dickkopf-Related Protein 2/DKK-2 (N-Fc, C-6His)
CC49-50ug	Novoprotein	50ug	EUR 442.8
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.2.

DKK-3 ELISA KIT\|Human
EF000091	Lifescience Market	96 Tests	EUR 826.8

DKK 3 Recombinant Protein
96-239	ProSci	0.2 mg	EUR 821.4
Description: Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK3 has been proposed as tumour suppressor gene and a marker for tumour blood vessels. DKK3 is the only DKK family member abundantly expressed in normal lung, but silenced by promoter hypermethylation in a large fraction of lung cancer cell lines and lung tumors. Downregulation of DKK3 was correlated with tumor progression and expression of nuclear beta-catenin in lung tumors. Ectopic expression of DKK3 in lung cancer cells with DKK3 hypermethylation induced apoptosis and inhibited TCF-4 activity as well as nuclear accumulation of beta-catenin and expression of TCF-4 targets c-Myc and cyclin D1. DKK3 modulates FGF and Activin/Nodal signaling to regulate mesoderm induction during early Xenopus development, was reported.

Recombinant Human Dkk-3 Protein
RP00355	Abclonal	10 μg	EUR 196.8

Dkk-1 ELISA Kit (Human) : 96 Wells (OKAG00221)
OKAG00221	Aviva Systems Biology	96 Wells	EUR 715.2
Description: Description of target: This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.;Species reactivity: Human;Application: ELISA;Assay info: Quantitative Colorimentric Sandwich ELISA;Sensitivity: 63 pg/mL

Human DKK-1(Dickkopf-related protein 1) ELISA Kit
EH0113	FN Test	96T	EUR 628.92

Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 18.75pg/ml

Recombinant Human Dkk-3/DKK3 Protein
RP00209	Abclonal	10 μg	EUR 186

Nori® Human DKK-1 ELISA Kit (2 plates)
GR106268-2	Genorise Scientific	2 x 96-well	EUR 832

Human DKK-4 PicoKine ELISA Kit
EK0868	BosterBio	96 wells	EUR 546
Description: For Quantitative Detection of human DKK-4 in cell culture supernates, serum and plasma(heparin, EDTA).

Human DKK-3 PicoKine ELISA Kit
EK1323	BosterBio	96 wells	EUR 510
Description: For quantitative detection of human DKK-3 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

DKK-3 ELISA Kit (Human) (OKBB00603)
OKBB00603	Aviva Systems Biology	96 Wells	EUR 606
Description: Description of target: Dickkopf-related protein 3 is a protein that in humans is encoded by the DKK3 gene. This gene encodes a protein that is a member of the dickkopf family. It is mapped to 11p15.3. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Members of the Dkk-related family display unique patterns of mRNA expression in human and mouse tissues, and are secreted when expressed in 293T cells. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: <= 10 pg/mL

Recombinant Dkk-1 Protein (Thr 32-His 266) [His]
VAng-1453Lsx-100g	Creative Biolabs	100 µg	EUR 1215.6
Description: Human Dkk-1, His tag, is expressed in HEK 293 cells. (Uniprot ID: NP_036374.1)

Recombinant Dkk-1 Protein (Thr 32-His 266) [His]
VAng-1453Lsx-1mg	Creative Biolabs	1 mg	EUR 5998.8
Description: Human Dkk-1, His tag, is expressed in HEK 293 cells. (Uniprot ID: NP_036374.1)

Recombinant Dkk-1 Protein (Thr 32-His 272) [His]
VAng-1455Lsx-500g	Creative Biolabs	500 µg	EUR 5338.8
Description: Mouse Dkk-1, His tag, is expressed in HEK 293 cells. (Uniprot ID: O54908)

Recombinant Dkk-1 Protein (Thr 32-His 272) [His]
VAng-1455Lsx-50g	Creative Biolabs	50 µg	EUR 1215.6
Description: Mouse Dkk-1, His tag, is expressed in HEK 293 cells. (Uniprot ID: O54908)

Recombinant Dkk-1 Protein (Thr 32-His 266) [Strep]
VAng-1454Lsx-1mg	Creative Biolabs	1 mg	EUR 7648.8
Description: Human Dkk-1, Fc tag, is expressed in HEK 293 cells. (Uniprot ID: NP_036374.1)

Recombinant Dkk-1 Protein (Thr 32-His 266) [Strep]
VAng-1454Lsx-250g	Creative Biolabs	250 µg	EUR 2964
Description: Human Dkk-1, Fc tag, is expressed in HEK 293 cells. (Uniprot ID: NP_036374.1)

Recombinant Dkk-1 Protein (Thr 32-His 266) [Strep]
VAng-1454Lsx-25g	Creative Biolabs	25 µg	EUR 918
Description: Human Dkk-1, Fc tag, is expressed in HEK 293 cells. (Uniprot ID: NP_036374.1)

Anti-Dkk-1 antibody
STJ97257	St John's Laboratory	200 µl	EUR 236.4
Description: Rabbit polyclonal to Dkk-1.

Anti-Dkk-1 antibody
STJ98000	St John's Laboratory	100 µl	EUR 280.8
Description: Mouse monoclonal to Dkk-1.

Recombinant Dkk-3 Protein (Pro 23-Ile 349) [His]
VAng-1456Lsx-1mg	Creative Biolabs	1 mg	EUR 6592.8
Description: Mouse Dkk-3, His tag, is expressed in HEK 293 cells. (Uniprot ID: NP_056629.1)

Recombinant Dkk-3 Protein (Pro 23-Ile 349) [His]
VAng-1456Lsx-50g	Creative Biolabs	50 µg	EUR 1017.6
Description: Mouse Dkk-3, His tag, is expressed in HEK 293 cells. (Uniprot ID: NP_056629.1)

Recombinant Dkk-3 Protein (Pro 23-Ile 350) [His]
VAng-1457Lsx-200g	Creative Biolabs	200 µg	EUR 1347.6
Description: Human Dkk-3, His tag, is expressed in HEK 293 cells. (Uniprot ID: NP_001018067.1)

Recombinant Dkk-3 Protein (Pro 23-Ile 350) [His]
VAng-1457Lsx-20g	Creative Biolabs	20 µg	EUR 456
Description: Human Dkk-3, His tag, is expressed in HEK 293 cells. (Uniprot ID: NP_001018067.1)

Human DKK-3(Dickkopf-related protein 3) ELISA Kit
EH0114	FN Test	96T	EUR 681.12

Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 37.5pg/ml

Anti-Dkk-3 antibody
STJ92720	St John's Laboratory	200 µl	EUR 236.4
Description: Rabbit polyclonal to Dkk-3.

Anti-Dkk-3 antibody
STJ98001	St John's Laboratory	100 µl	EUR 280.8
Description: Mouse monoclonal to Dkk-3.

IGF-1-Fc
E13-m003-1	EnoGene	10μg	EUR 349.2

IGF-1-Fc
E13-m003-2	EnoGene	50μg	EUR 996

Frizzled-1, Fc fusion
71123	BPS Bioscience	50 µg	EUR 325
Description: Secreted frizzled receptor (FZD1)-Fc fusion_x000D_protein and WNT receptor, also known as_x000D_FZD1, GenBank Accession No.BC_051271,_x000D_a.a. 73-253, expressed in a HEK293 cell_x000D_expression system. MW = 46.4 kDa_x000D_(monomer). This protein runs at a higher_x000D_apparent M.W. by SDS-PAGE due to_x000D_glycosylation.

Contactin-1, FC Chimera
PR15072	Neuromics	100 ug	EUR 568.8

TIE-1 Fc Chimera
PR27153	Neuromics	2 ug	EUR 229.2

Fc
EF006811	Lifescience Market	96 Tests	EUR 826.8

Fc
EF006812	Lifescience Market	96 Tests	EUR 826.8

Fc
EF006814	Lifescience Market	96 Tests	EUR 826.8

Fc
EF006815	Lifescience Market	96 Tests	EUR 826.8

B7-1 (CD80), Fc fusion
71125	BPS Bioscience	100 µg	EUR 320
Description: Human secreted B7-1-Fc fusion protein, also known as CD80. GenBank Accession No. NM_005191, a.a. 35-242 expressed in a HEK293 cell expression system. MW = 50.5 kDa (monomer). This protein runs at a higher M.W. by SDS-PAGE due to glycosylation.

PD-1, Fc Fusion (Woodchuck)
79314	BPS Bioscience	100 µg	EUR 320
Description: Woodchuck (Groundhog, Marmota monax) secreted programmed cell death 1 (PD-1) also known as, PDCD1, SLEB2, CD279 and HPD-L, GenBank Accession No. HQ403652.1, a.a 25-172, fused at the C-terminus to the Fc portion of Human IgG1, expressed in a HEK293 cell expression system. MW = 43 kDa. This protein runs at a higher M.W. by SDS-PAGE due to glycosylation.

B7-1 Fc Recombinant Protein
40-693	ProSci	20 ug	EUR 311.1
Description: B7-1 and B7-2 are transmembrane glycoproteins of the immunoglobulin superfamily that are expressed, along with the receptors CD28 and CTLA-4, by antigen-presenting cells, and along with these receptors, constitute crucial co-stimulatory pathways for T and B cell regulatory responses. As members of the B7 family, B7-1 and B7-2 play principal roles in immunity, activating immune response and maintaining immune tolerance through engagement with CD28 and CTLA-4. Co-stimulatory signals generated by B7-1 and B7-2 interactions with CD28 serve to stimulate T cell activation and prevent anergy through the amplification of T cell receptor (TCR) signaling. In contrast, interactions of the ligands with CTLA-4 serves to maintain T cell homeostasis and self-tolerance through the disruption of stimulatory signaling from B7 isoform bound CD28 complexes, and by inducing powerful inhibitory signals in T cells. B7-1 plays an important role in immune response through its amplification and regulation of T cell activity at peripheral inflammation sites. B7-1, like CTLA-4, is, however, only poorly expressed on resting dendritic cells, and its up-regulation is, therefore, considerably delayed upon immune activation. Conversely, B7-2 and CD28 are constitutively expressed by resting hematopoietic and T cells, respectively, and as a result are able to rapidly induce up-regulation upon immune activation, making them critical to the early co-stimulatory singling of immune response. Both B7-1 and B7-2 have been shown to demonstrate co-stimulatory activity in T cell proliferation in vitro and elicit enhanced antitumor immune response in vivo. Recombinant Human B7-1Fc is a homodimeric B7-1 fusion protein, whose monomer contains a total of 441 amino acid residues, consisting of 211 amino acid residues corresponding to the extracellular domain of human B7-1, fused to the Fc portion of human IgG1. The calculated molecular weight of the B7-1 Fc monomer is 50.0 kDa.

TREM-1-Fc Recombinant Protein
40-697	ProSci	10 ug	EUR 311.1
Description: Triggering receptor expressed on myeloid cells-1 (TREM-1) is a type 1 transmembrane glycoprotein belonging to the immunoglobulin superfamily of cell surface receptors that is constitutively expressed on the surface of monocytes, neutrophils and macrophages. The first identified member of the TREM family of receptors, TREM-1 is a proponent of amplified inflammatory responses triggered by bacterial and fungal infection, and functions in association with the signal transduction adaptor molecule DAP12. TREM-1 activation induces the sustained secretion of proinflammatory chemokines (IL-8 and MCP-1) and cytokines (TNF-α, IL-1β, and IL-6), the respiratory burst and degranulation of neutrophils, the upregulation of adhesion molecules involved in leukocyte extravasation, and tissue degradation. Involvement and increased expression of TREM-1, or soluble TREM-1, in infectious, as well as some non-infectious, inflammatory conditions may highlight the protein’s potential as a possible diagnostic marker in cases of severe inflammation, such as myocardial dysfunction related to severe sepsis and spontaneous preterm labor. TREM-1 involvement in inflammatory response has also been noted as a predictor of both progression and aggression in certain cancers. CHO cell-derived Recombinant Human TREM-1 Fc is a glycosylated, disulfide-linked homodimer of 826 amino acid residues whose monomer consists of the 180-amino-acid length extracellular portion of TREM-1 fused to the 231-amino-acid length Fc portion of human IgG1 by two glycines. The calculated molecular weight of Recombinant Human TREM-1 Fc dimer is 92.6 kDa; however, due to glycosylation, the monomer and dimer migrate at apparent molecular weights of approximately 60-65 kDa and 110-116 kDa by SDS-PAGE analysis under reducing conditions.

PD-1/PDCD1(Fc fusion)
E21-J97	EnoGene	10ug	EUR 411.6

FC Antibody
48379-100ul	SAB	100ul	EUR 399.6

FC Antibody
48379-50ul	SAB	50ul	EUR 286.8

IgG1, Fc
71456	BPS Bioscience	200 µg	EUR 265
Description: Fc region of human immunoglobulin G1 (IgG1) protein, also known as Il-4, GenBank Accession No. P01857, a.a. 100-330, expressed in an HEK293 cell expression system. MW = 27 kDa.

IgG4, Fc
71457	BPS Bioscience	200 µg	EUR 265
Description: Fc region of human immunoglobulin G4 (IgG4) protein, a.a. 99-327, Genbank Accession #P01861, expressed in an HEK293 cell expression system. MW = 27 kDa.

FC 131
B7647-1	ApexBio	1 mg	EUR 224.4

FC 131
B7647-10	ApexBio	10 mg	EUR 1382.4

FC 131
B7647-5	ApexBio	5 mg	EUR 804

SCF-Fc
E13-m004-1	EnoGene	10μg	EUR 411.6

SCF-Fc
E13-m004-2	EnoGene	50μg	EUR 1308

pMac- FC
PVT11383	Lifescience Market	2 ug	EUR 444

Notoginsenoside Fc
TBZ2655	ChemNorm	20mg	Ask for price

Recombinant Human TIE-1 Fc Chimera
7-04183	CHI Scientific	1µg	Ask for price

Recombinant Human TIE-1 Fc Chimera
7-04184	CHI Scientific	3µg	Ask for price

Recombinant Human TIE-1 Fc Chimera
7-04185	CHI Scientific	100µg	Ask for price

Recombinant Mouse TIE-1 Fc Chimera
7-04186	CHI Scientific	1µg	Ask for price

Recombinant Mouse TIE-1 Fc Chimera
7-04187	CHI Scientific	3µg	Ask for price

Recombinant Mouse TIE-1 Fc Chimera
7-04188	CHI Scientific	100µg	Ask for price

PD-1 (CD279), Fc fusion (Human)
71106-1	BPS Bioscience	100 µg	EUR 345
Description: Human secreted programmed cell death 1 (PD-1)-Fc fusion protein, also known as, PDCD1, SLEB2, CD279 and HPD-L, GenBank Accession No. NM_005018, a.a 25-167, fused at the C-terminus to the Fc portion of human IgG1, expressed in a HEK293 cell expression system. MW = 42.6 kDa. This protein runs at a higher M.W. by SDS-PAGE due to glycosylation.

PD-1 (CD279), Fc fusion (Human)
71106-2	BPS Bioscience	1 mg	EUR 2755
Description: Human secreted programmed cell death 1 (PD-1)-Fc fusion protein, also known as, PDCD1, SLEB2, CD279 and HPD-L, GenBank Accession No. NM_005018, a.a 25-167, fused at the C-terminus to the Fc portion of human IgG1, expressed in a HEK293 cell expression system. MW = 42.6 kDa. This protein runs at a higher M.W. by SDS-PAGE due to glycosylation.

Mouse PD-1 (CD279), Fc fusion
71116	BPS Bioscience	100 µg	EUR 335
Description: Mouse secreted Programmed Cell Death 1_x000D_(PD-1)-Fc fusion protein, also known as_x000D_CD279, PDCD1, and SLEB2, GenBank_x000D_Accession No. NM_008798, a.a. 25-167,_x000D_fused at the C-terminus to the Fc portion of_x000D_mouse IgG2a, expressed in a HEK293 cell_x000D_expression system. MW = 43.2 kDa. Note:_x000D_this protein runs at an apparent higher_x000D_molecular weight due to glycosylation.

PD-1, Fc Fusion, PE-labeled
71243-1	BPS Bioscience	50 µg	EUR 455
Description: Human secreted programmed cell death 1 (PD-1)-Fc fusion protein, also known as, PDCD1, SLEB2, CD279 and HPD-L, GenBank Accession No. NM_005018, a.a 25-167, fused at the Cterminus to the Fc portion of human IgG1, expressed in a HEK293 cell expression system. This protein runs at a higher M.W. by SDS-PAGE due to glycosylation. The protein was randomly labeled with RPE on accessible lysine residues.

PD-1, Fc fusion, Avi-Tag
100406	BPS Bioscience	100 µg	EUR 320
Description: Human secreted programmed cell death 1 (PD-1), also known as PDCD1, SLEB2, CD279 and HPD-L, GenBank Accession No. NM_005018, a.a 25-167, fused at the C-terminus to the Fc portion of human IgG1, with C-terminal Avi-tag™ expressed in a HEK293 cell expression system. MW = 44.5 kDa.

TIE-1 Fc Chimera Protein (Recombinant)
20-abx073607	Abbexa	EUR 393.60 EUR 5672.40 EUR 276.00	10 ug 1 mg 2 µg

TIE-1 Fc Chimera Protein (Recombinant)
20-abx073608	Abbexa	EUR 393.60 EUR 5672.40 EUR 276.00	10 ug 1 mg 2 µg

PDCD1/PD-1/CD279 (Fc fusion)
E21-M81	EnoGene	10ug	EUR 411.6

VCAM-1/CD106, Fc Chimera, CF
PR15087CF	Neuromics	100 ug	EUR 841.2

Human Immunoglobulin G1-Fc (IgG1-Fc) Antibody
34105-05111	AssayPro	150 ug	EUR 313.2

Human Immunoglobulin G3-Fc (IgG3-Fc) Antibody
34107-05111	AssayPro	150 ug	EUR 313.2

Human Immunoglobulin G4-Fc (IgG4-Fc) Antibody
34108-05111	AssayPro	150 ug	EUR 313.2

Human Immunoglobulin G2-Fc (IgG2-Fc) Antibody
34106-05111	AssayPro	150 ug	EUR 313.2

TIE1-Fc TIE1 Fc Human Recombinant Protein
PROTP35590	BosterBio	Regular: 10ug	EUR 380.4
Description: Soluble TIE-1 Human Recombinant fused with the Fc part of human IgG1 produced in baculovirus is a homodimeric, glycosylated, polypeptide containing 749 amino acids and having a total molecular mass of 250 kDa. Human TIE-1/Fc monomer has a calculated molecular mass of approximately 105 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 125 kDa protein in SDS-PAGE under reducing conditions.;The TIE1 Fc Chimera is purified by proprietary chromatographic techniques.

Recombinant Human Mucin-1/MUC-1 (C-Fc)
CS58-10ug	Novoprotein	10ug	EUR 169.2
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Human Mucin-1/MUC-1 (C-Fc)
CS58-1mg	Novoprotein	1mg	EUR 2008.8
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Human Mucin-1/MUC-1 (C-Fc)
CS58-500ug	Novoprotein	500ug	EUR 1423.2
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Human Mucin-1/MUC-1 (C-Fc)
CS58-50ug	Novoprotein	50ug	EUR 363.6
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

The Japanese Onco-Cardiology Society was established in 2017, and continues integration of academic activities to solve challenging problems in this field. Interdisciplinary collaborations between cardiologists and oncologists will be further progressed in medical care, clinical and basic research, and education.