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The Utility of a Formative One-Station Objective Structured Clinical Examination for Substance Use Disorders in a Dental Curriculum

The Utility of a Formative One-Station Objective Structured Clinical Examination for Substance Use Disorders in a Dental Curriculum

Substance Use Disorders (SUD) are chronic relapsing medical conditions characterized by compulsive substance seeking and use. They constitute a substantial disease burden globally. Labeling of persons with SUD has created barriers to treatment but there are effective management strategies. The dental profession has embraced reforms designed to address the SUD epidemic by promoting continuing education for practitioners and initiating curriculum changes in dental schools. Screening, Brief Intervention and Referral to Treatment (SBIRT) is an evidence-based model for managing patients with SUD.

The use of a formative 1-station Objective Structured Clinical Examination (OSCE) for learning and assessment in SBIRT, operationalized with the MD3 rating scale is presented in this study. In 3 years of implementation, the SBIRT OSCE successfully integrated into the curriculum of the College of Dental Medicine, Columbia University. Mean score of total adherent behaviours was 11.80 (SD = 4.23) (range: 2 – 24) and Cronbach’s coefficient alpha for across-items reliability in adherent behaviours was 0.66. Adherent behaviours correlated with the global ratings (r = 0.66). Mean of global rating scores were 2.90 (SD = 1.01) for collaboration and 2.97 (SD = 1.00) for empathy and the global rating scores correlated with each other (r = 0.85). Histograms of global rating scores resembled normal distribution. The 1-station OSCE is a good model for learning about SBIRT. Psychometric analysis was useful in understanding the underlying construct of the MD3 rating scale and supported its reliability, validity and utility in dental education.

Delivering online alternatives to the anatomy laboratory: early experience during the COVID-19 pandemic

Social distancing measures due to the COVID-19 pandemic will make anatomy dissecting room practicals difficult, if not impossible to run at some institutions in the upcoming academic year. The learning community that exists within physical anatomy practicals needs to be moved online. Virtual replacement of visuo-spatial and social elements of learning anatomy pose particular challenges to educators.

Our department has trialled Blackboard Collaborate, an online communication platform in conjunction with Visible Body, a 3D anatomical modelling program. We have delivered 266 hours of synchronous small group teaching to medical and physician associate students. We describe this approach and discuss the relevance of distance learning pedagogy to the design of new online anatomy teaching and development of online learning communities. This article is protected by copyright. All rights reserved.

Attitudes of key professionals towards people with intellectual disabilities and their inclusion in society: A qualitative study in an Indonesian context

This study aimed to explore key professionals’ attitudes towards people with intellectual disability (ID) and inclusion of said people in the community. Eighteen participants from three professional groups, comprising health practitioners (medical doctors, psychologists), mainstream/special education teachers, and religious leaders (Islam, Catholicism, Protestantism, Hinduism, and Buddhism) were recruited. Semistructured interviews, aided by two vignettes depicting mild and severe ID, were conducted.

Thematic analysis was used to analyse the data. Seven themes were identified exploring: perceived causes; use of terminology; attitudes towards people with ID; attitudes towards inclusion, religion and ID; family-centric support; and challenges faced by people with ID in a wider context. Perceived capabilities of persons with ID were found to influence attitudes towards people with ID and their inclusion. Availability and accessibility of good quality services were also found to influence attitudes towards the inclusion of people with ID. Cultural factors related to attitudes towards ID are discussed.

The Great Gamble? A Mixed-Methods Study of Factors In˜fluencing Medical Students in Specialty Choice

Career planning remains relatively unexplored as a domain of medical education. Our aim was to explore the career planning journey undertaken by medical students. Results Approximately one third of participants had decided their future specialty. Important factors in career choice were ‘interest in specific [specialty] aspects,’ ‘work-life balance,’ ‘personality type’ of others in the specialty, an enjoyable experience on rotation and role models. Negative influential factors included poor conduct of doctors encountered and negative portrayals of specialities by practicing doctors. Conclusion The undergraduate and early postgraduate periods are formative times in career planning for junior doctors. Students and interns/FY1s are strongly influenced by doctors in the clinical setting, and clinicians should be aware of this power to exert both positive and negative influence.

The Utility of a Formative One-Station Objective Structured Clinical Examination for Substance Use Disorders in a Dental Curriculum

Dawning of Onco-Cardiology

Recent progress in cancer therapy has decreased all-cancer mortality, but cardiovascular adverse events owing to chemotherapy and radiotherapy have greater impact on clinical outcome and quality of life in cancer patients and survivors. There are a wide variety of cardiovascular adverse events related to cancer therapy, and the opportunities requiring specialized care by cardiovascular experts are increasing in clinical practice. Under such circumstances, onco-cardiology is becoming very important as a new discipline and attracting much attention in Japan.

Recombinant Dkk-1 Protein (Thr 32-His 266) [Fc]

VAng-1451Lsx-1mg 1 mg
EUR 5668.8
Description: Human Dkk-1, Fc tag, is expressed in HEK 293 cells. (Uniprot ID: NP_036374.1)

Human Dkk-1

MBS691712-0002mg 0.002mg
EUR 300

Human Dkk-1

MBS691712-001mg 0.01mg
EUR 450

Human Dkk-1

MBS691712-5x001mg 5x0.01mg
EUR 1725

Human Dkk-1

MBS692271-0005mg 0.005mg
EUR 250

Human Dkk-1

MBS692271-002mg 0.02mg
EUR 360

Human Dkk-1

MBS692271-5x002mg 5x0.02mg
EUR 1325

DKK-1 Antibody

F51803-0.4ML 0.4 ml
EUR 322.15
Description: DKK-1 is a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK-1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.

Dkk-1 Antibody

C30180-100ul 100μl
EUR 217
Description: Dkk-1 Rabbit Polyclonal Antibody

Dkk-1 Antibody

C30180-50ul 50μl
EUR 143.5
Description: Dkk-1 Rabbit Polyclonal Antibody

Recombinant Human Dickkopf-Related Protein 1/DKK-1 (C-Fc)

PKSH034024-10ug 10ug
EUR 100
Description: Human

Recombinant Human Dickkopf-Related Protein 1/DKK-1 (C-Fc)

PKSH034024-50ug 50ug
EUR 300
Description: Human

Recombinant Human Dickkopf-Related Protein 1/DKK-1 (C-Fc)

MBS2569207-001mg 0.01mg
EUR 160

Recombinant Human Dickkopf-Related Protein 1/DKK-1 (C-Fc)

MBS2569207-005mg 0.05mg
EUR 310

Recombinant Human Dickkopf-Related Protein 1/DKK-1 (C-Fc)

MBS2569207-5x005mg 5x0.05mg
EUR 1395

Recombinant Dkk-1 Protein (Thr 32-His 266) [Fc] [Avi]

VAng-1452Lsx-200g 200 µg
EUR 4612.8
Description: Biotinylated Human Dkk-1, Fc tag and Avi tag, is expressed in HEK 293 cells. (Uniprot ID: O94907-1)

Recombinant Dkk-1 Protein (Thr 32-His 266) [Fc] [Avi]

VAng-1452Lsx-25g 25 µg
EUR 1215.6
Description: Biotinylated Human Dkk-1, Fc tag and Avi tag, is expressed in HEK 293 cells. (Uniprot ID: O94907-1)

Dkk-1 Rabbit pAb

E2251891 100ul
EUR 225
Description: Available in various conjugation types.

DKK-1 Rabbit pAb

MBS8540496-01mL 0.1mL
EUR 305

DKK-1 Rabbit pAb

MBS8540496-01mLAF405L 0.1mL(AF405L)
EUR 565

DKK-1 Rabbit pAb

MBS8540496-01mLAF405S 0.1mL(AF405S)
EUR 565

DKK-1 Rabbit pAb

MBS8540496-01mLAF610 0.1mL(AF610)
EUR 565

DKK-1 Rabbit pAb

MBS8540496-01mLAF635 0.1mL(AF635)
EUR 565

Dkk-1 (mouse), (recombinant)

MBS566756-0005mg 0.005mg
EUR 330

Dkk-1 (mouse), (recombinant)

MBS566756-5x0005mg 5x0.005mg
EUR 1420

Dkk-1 Recombinant Protein

96-861 0.1 mg
EUR 651.3
Description: Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway, binds to LRP6 with high affinity and prevents the Frizzled-Wnt-LRP6 complex formation in response to Wnts. DKK1 promotes LRP6 internalization and degradation when it forms a ternary complex with the cell surface receptor Kremen.DKK1 not olny functions as a head inducer during development, but also regulates joint remodeling and bone formation, which suggests roles for DKK1 in the pathogenesis of rheumatoid arthritis and multiple myeloma. More recently research reported, DKK1 impacts eye development from a defined developmental time point on, and is critical for lens separation from the surface ectoderm via beta-catenin mediated Pdgfralpha and E-cadherin expression.

Dkk-1 Recombinant Protein

96-990 0.05 mg
EUR 714.3
Description: Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway, binds to LRP6 with high affinity and prevents the Frizzled-Wnt-LRP6 complex formation in response to Wnts. DKK1 promotes LRP6 internalization and degradation when it forms a ternary complex with the cell surface receptor Kremen.DKK1 not olny functions as a head inducer during development, but also regulates joint remodeling and bone formation, which suggests roles for DKK1 in the pathogenesis of rheumatoid arthritis and multiple myeloma. More recently research reported, DKK1 impacts eye development from a defined developmental time point on, and is critical for lens separation from the surface ectoderm via beta-catenin mediated Pdgfralpha and E-cadherin expression.

Dkk-1 Polyclonal Antibody

ABP53293-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of Dkk-1 from Human, Mouse, Rat. This Dkk-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Dkk-1

Dkk-1 Polyclonal Antibody

ABP53293-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of Dkk-1 from Human, Mouse, Rat. This Dkk-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Dkk-1

Dkk-1 Polyclonal Antibody

ABP53293-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of Dkk-1 from Human, Mouse, Rat. This Dkk-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Dkk-1

Dkk-1 Polyclonal Antibody

41928-100ul 100ul
EUR 302.4

Dkk-1 Polyclonal Antibody

41928-50ul 50ul
EUR 224.4

DKK-1 Recombinant Protein

40-225-0002mg 0.002 mg
EUR 311.1
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues.

DKK-1 Recombinant Protein

40-225-001mg 0.01 mg
EUR 437.1
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues.

Dkk-1 Polyclonal Antibody

E041928 100μg/100μl
EUR 255
Description: Available in various conjugation types.

Dkk-1 Polyclonal Antibody

E20-75562 100ug
EUR 225
Description: Available in various conjugation types.

Dkk-1 Monoclonal Antibody

BT-MCA0444-100ul 100ul Ask for price
Description: This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.

Dkk-1 Monoclonal Antibody

BT-MCA0444-50ul 50ul Ask for price
Description: This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.

Dkk-1 Polyclonal Antibody

E44H07004 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Dkk-1 Polyclonal Antibody

BT-AP02622-100ul 100ul Ask for price
Description: DKK1 encodes dickkopf WNT signaling pathway inhibitor 1 that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.

Dkk-1 Polyclonal Antibody

BT-AP02622-20ul 20ul Ask for price
Description: DKK1 encodes dickkopf WNT signaling pathway inhibitor 1 that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.

Dkk-1 Polyclonal Antibody

BT-AP02622-50ul 50ul Ask for price
Description: DKK1 encodes dickkopf WNT signaling pathway inhibitor 1 that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.

Dkk-1 Polyclonal Antibody

MBS9246178-01mL 0.1mL
EUR 415

Dkk-1 Polyclonal Antibody

MBS9246178-5x01mL 5x0.1mL
EUR 1841

Dkk-1 Polyclonal Antibody

MBS9409972-005mL 0.05mL
EUR 245

Dkk-1 Polyclonal Antibody

MBS9409972-01mL 0.1mL
EUR 305

Dkk-1 Polyclonal Antibody

MBS9409972-5x01mL 5x0.1mL
EUR 1230

Dkk-1 Polyclonal Antibody

MBS8526543-01mg 0.1mg
EUR 305

Dkk-1 Polyclonal Antibody

MBS8526543-01mLAF405L 0.1mL(AF405L)
EUR 465

Dkk-1 Polyclonal Antibody

MBS8526543-01mLAF405S 0.1mL(AF405S)
EUR 465

Dkk-1 Polyclonal Antibody

MBS8526543-01mLAF610 0.1mL(AF610)
EUR 465

Dkk-1 Polyclonal Antibody

MBS8526543-01mLAF635 0.1mL(AF635)
EUR 465

Dkk-1 Polyclonal Antibody

MBS2534622-002mL 0.02mL
EUR 140

Dkk-1 Polyclonal Antibody

MBS2534622-006mL 0.06mL
EUR 180

Dkk-1 Polyclonal Antibody

MBS2534622-012mL 0.12mL
EUR 260

Dkk-1 Polyclonal Antibody

MBS2534622-02mL 0.2mL
EUR 405

DKK-1 Neutralizing Antibody

MBS8101470-02mg 0.2mg
EUR 280

DKK-1 Neutralizing Antibody

MBS8101470-05mg 0.5mg
EUR 375

DKK-1 Neutralizing Antibody

MBS8101470-5x05mg 5x0.5mg
EUR 1545

Dkk-2

GT15222 100 ug
EUR 631.2

DKK 1 Recombinant Protein

96-236 0.1 mg
EUR 752.1
Description: Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway, binds to LRP6 with high affinity and prevents the Frizzled-Wnt-LRP6 complex formation in response to Wnts. DKK1 promotes LRP6 internalization and degradation when it forms a ternary complex with the cell surface receptor Kremen.DKK1 not olny functions as a head inducer during development, but also regulates joint remodeling and bone formation, which suggests roles for DKK1 in the pathogenesis of rheumatoid arthritis and multiple myeloma. More recently research reported, DKK1 impacts eye development from a defined developmental time point on, and is critical for lens separation from the surface ectoderm via β-catenin mediated Pdgfrα and E-cadherin expression.

DKK 1 Recombinant Protein

96-237 0.025 mg
EUR 619.8
Description: Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway, binds to LRP6 with high affinity and prevents the Frizzled-Wnt-LRP6 complex formation in response to Wnts. DKK1 promotes LRP6 internalization and degradation when it forms a ternary complex with the cell surface receptor Kremen.DKK1 not olny functions as a head inducer during development, but also regulates joint remodeling and bone formation, which suggests roles for DKK1 in the pathogenesis of rheumatoid arthritis and multiple myeloma. More recently research reported, DKK1 impacts eye development from a defined developmental time point on, and is critical for lens separation from the surface ectoderm via β-catenin mediated Pdgfrα and E-cadherin expression.

Rat DKK-1 ELISA Kit

EK5668 96 tests
EUR 599

Dkk-1 (Human) ELISA Kit

EKA52037-5x96T 5x96T Ask for price

Dkk-1 (Human) ELISA Kit

EKA52037-96T 96T
EUR 446.9

Human Dkk-1 ELISA KIT

E42EH-269 96T/48T Ask for price

Mouse Dkk-1 ELISA KIT

E42EM-173 96T/48T Ask for price

Human Dkk-1 ELISA Kit

E28L0566 96T
EUR 666.67

Mouse Dkk-1 ELISA Kit

E28L0661 96T
EUR 666.67

Human DKK-1 ELISA Kit

EK5390 96 tests
EUR 599

Human DKK-1 ELISA KIT

EF000090 96tests
EUR 566

Human Dkk-1 ELISA Kit

GWB-SKR221 96 Tests Ask for price

Human DKK-1 ELISA kit

LF-EK50797 1×96T
EUR 777.6

Recombinant Human DKK-2/DKK2 Protein, Fc Tag & His Tag.

E40KMH987 20ug
EUR 495

Anti-Human Dkk-1 Antibody

101-M380 100 µg
EUR 399
Description: Dkk1 is a Dickkopf-related protein that inhibits Wnt signaling by binding the Wnt coreceptor LRP5/6. It also binds Kremen1 and Kremen2. Dkk1 is important in embryonic development.

Anti-Human Dkk-1 Antibody

101-M426 100 µg
EUR 399
Description: Dkk1 is a Dickkopf-related protein that inhibits Wnt signaling by binding the Wnt coreceptor LRP5/6. It also binds Kremen1 and Kremen2. Dkk1 is important in embryonic development.

Anti-Human Dkk-1 Antibody

102-PA33 200 µg
EUR 204.75
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 fused to a C terminal His-tag derived from E. coli is a 26 kDa protein containing 235 amino-acid residues.

Anti-Human Dkk-1 Antibody

102-PA33S 100 µg
EUR 126
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 fused to a C terminal His-tag derived from E. coli is a 26 kDa protein containing 235 amino-acid residues.

DKK-1 (CHO-expressed), Mouse

HY-P7154 50ug
EUR 914.4

DKK-1 (HEK293-expressed), Human

HY-P7155A 50ug
EUR 1011.6

human Dkk-1 Recombinant Protein

100-407 10 µg
EUR 196.35
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues.

human Dkk-1 Recombinant Protein

100-407S 2 µg
EUR 92.4
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues.

Human Dkk-1 Recombinant Protein

200-013 20 µg
EUR 136.5
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 fused to a C terminal His-tag derived from E. coli is a 26 kDa protein containing 235 amino-acid residues.

Human Dkk-1 Recombinant Protein

200-013S 5 µg
EUR 92.4
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 fused to a C terminal His-tag derived from E. coli is a 26 kDa protein containing 235 amino-acid residues.

Recombinant Human DKK-1 Protein

PROTO94907-3 10ug
EUR 380.4
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues.

Recombinant Mouse Dkk-1 Protein

MBS9141892-0005mg 0.005mg
EUR 165

Recombinant Mouse Dkk-1 Protein

MBS9141892-002mg 0.02mg
EUR 235

Recombinant Mouse Dkk-1 Protein

MBS9141892-005mg 0.05mg
EUR 435

Recombinant Mouse Dkk-1 Protein

MBS9141892-01mg 0.1mg
EUR 650

Recombinant Mouse Dkk-1 Protein

MBS9141892-5x01mg 5x0.1mg
EUR 2750

Recombinant mouse Dkk-1 protein

MBS201385-001mg 0.01mg
EUR 240

Recombinant mouse Dkk-1 protein

MBS201385-002mg 0.02mg
EUR 320

Recombinant mouse Dkk-1 protein

MBS201385-005mg 0.05mg
EUR 375

Recombinant mouse Dkk-1 protein

MBS201385-01mg 0.1mg
EUR 550

Recombinant mouse Dkk-1 protein

MBS201385-025mg 0.25mg
EUR 885

Dkk-1 Rabbit Polyclonal Antibody

ES4292-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against Dkk-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Dkk-1 Rabbit Polyclonal Antibody

ES4292-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against Dkk-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Dkk-1 Polyclonal Conjugated Antibody

C41928 100ul
EUR 476.4

Dkk-1 Polyclonal Conjugated Antibody

MBS9450395-01mLAF350 0.1mL(AF350)
EUR 480

Dkk-1 Polyclonal Conjugated Antibody

MBS9450395-01mLAF405 0.1mL(AF405)
EUR 480

Dkk-1 Polyclonal Conjugated Antibody

MBS9450395-01mLAF488 0.1mL(AF488)
EUR 480

Dkk-1 Polyclonal Conjugated Antibody

MBS9450395-01mLAF555 0.1mL(AF555)
EUR 480

Dkk-1 Polyclonal Conjugated Antibody

MBS9450395-01mLBiotin 0.1mL(Biotin)
EUR 480

DKK1 (Dickkopf-1, DKK-1, SK) (AP)

MBS6414187-01mL 0.1mL
EUR 950

DKK1 (Dickkopf-1, DKK-1, SK) (AP)

MBS6414187-5x01mL 5x0.1mL
EUR 4120

DKK1 (Dickkopf-1, DKK-1, SK) (PE)

MBS6414197-01mL 0.1mL
EUR 950

DKK1 (Dickkopf-1, DKK-1, SK) (PE)

MBS6414197-5x01mL 5x0.1mL
EUR 4120

DKK1 (Dickkopf-1, DKK-1, SK) (AP)

MBS6414198-01mL 0.1mL
EUR 950

DKK1 (Dickkopf-1, DKK-1, SK) (AP)

MBS6414198-5x01mL 5x0.1mL
EUR 4120

DKK1 (Dickkopf-1, DKK-1, SK) (PE)

MBS6414208-01mL 0.1mL
EUR 950

DKK1 (Dickkopf-1, DKK-1, SK) (PE)

MBS6414208-5x01mL 5x0.1mL
EUR 4120

DKK1 (Dickkopf-1, DKK-1, SK) (APC)

MBS6414188-01mL 0.1mL
EUR 950

DKK1 (Dickkopf-1, DKK-1, SK) (APC)

MBS6414188-5x01mL 5x0.1mL
EUR 4120

DKK1 (Dickkopf-1, DKK-1, SK) (HRP)

MBS6414191-01mL 0.1mL
EUR 950

DKK1 (Dickkopf-1, DKK-1, SK) (HRP)

MBS6414191-5x01mL 5x0.1mL
EUR 4120

DKK1 (Dickkopf-1, DKK-1, SK) (APC)

MBS6414199-01mL 0.1mL
EUR 950

The Japanese Onco-Cardiology Society was established in 2017, and continues integration of academic activities to solve challenging problems in this field. Interdisciplinary collaborations between cardiologists and oncologists will be further progressed in medical care, clinical and basic research, and education.

 

 

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