The Utility of a Formative One-Station Objective Structured Clinical Examination for Substance Use Disorders in a Dental Curriculum

Substance Use Disorders (SUD) are chronic relapsing medical conditions characterized by compulsive substance seeking and use. They constitute a substantial disease burden globally. Labeling of persons with SUD has created barriers to treatment but there are effective management strategies. The dental profession has embraced reforms designed to address the SUD epidemic by promoting continuing education for practitioners and initiating curriculum changes in dental schools. Screening, Brief Intervention and Referral to Treatment (SBIRT) is an evidence-based model for managing patients with SUD.

The use of a formative 1-station Objective Structured Clinical Examination (OSCE) for learning and assessment in SBIRT, operationalized with the MD3 rating scale is presented in this study. In 3 years of implementation, the SBIRT OSCE successfully integrated into the curriculum of the College of Dental Medicine, Columbia University. Mean score of total adherent behaviours was 11.80 (SD = 4.23) (range: 2 – 24) and Cronbach’s coefficient alpha for across-items reliability in adherent behaviours was 0.66. Adherent behaviours correlated with the global ratings (r = 0.66). Mean of global rating scores were 2.90 (SD = 1.01) for collaboration and 2.97 (SD = 1.00) for empathy and the global rating scores correlated with each other (r = 0.85). Histograms of global rating scores resembled normal distribution. The 1-station OSCE is a good model for learning about SBIRT. Psychometric analysis was useful in understanding the underlying construct of the MD3 rating scale and supported its reliability, validity and utility in dental education.

Delivering online alternatives to the anatomy laboratory: early experience during the COVID-19 pandemic

Social distancing measures due to the COVID-19 pandemic will make anatomy dissecting room practicals difficult, if not impossible to run at some institutions in the upcoming academic year. The learning community that exists within physical anatomy practicals needs to be moved online. Virtual replacement of visuo-spatial and social elements of learning anatomy pose particular challenges to educators.

Our department has trialled Blackboard Collaborate, an online communication platform in conjunction with Visible Body, a 3D anatomical modelling program. We have delivered 266 hours of synchronous small group teaching to medical and physician associate students. We describe this approach and discuss the relevance of distance learning pedagogy to the design of new online anatomy teaching and development of online learning communities. This article is protected by copyright. All rights reserved.

Attitudes of key professionals towards people with intellectual disabilities and their inclusion in society: A qualitative study in an Indonesian context

This study aimed to explore key professionals’ attitudes towards people with intellectual disability (ID) and inclusion of said people in the community. Eighteen participants from three professional groups, comprising health practitioners (medical doctors, psychologists), mainstream/special education teachers, and religious leaders (Islam, Catholicism, Protestantism, Hinduism, and Buddhism) were recruited. Semistructured interviews, aided by two vignettes depicting mild and severe ID, were conducted.

Thematic analysis was used to analyse the data. Seven themes were identified exploring: perceived causes; use of terminology; attitudes towards people with ID; attitudes towards inclusion, religion and ID; family-centric support; and challenges faced by people with ID in a wider context. Perceived capabilities of persons with ID were found to influence attitudes towards people with ID and their inclusion. Availability and accessibility of good quality services were also found to influence attitudes towards the inclusion of people with ID. Cultural factors related to attitudes towards ID are discussed.

The Great Gamble? A Mixed-Methods Study of Factors In˜fluencing Medical Students in Specialty Choice

Career planning remains relatively unexplored as a domain of medical education. Our aim was to explore the career planning journey undertaken by medical students. Results Approximately one third of participants had decided their future specialty. Important factors in career choice were ‘interest in specific [specialty] aspects,’ ‘work-life balance,’ ‘personality type’ of others in the specialty, an enjoyable experience on rotation and role models. Negative influential factors included poor conduct of doctors encountered and negative portrayals of specialities by practicing doctors. Conclusion The undergraduate and early postgraduate periods are formative times in career planning for junior doctors. Students and interns/FY1s are strongly influenced by doctors in the clinical setting, and clinicians should be aware of this power to exert both positive and negative influence.

Dawning of Onco-Cardiology

Recent progress in cancer therapy has decreased all-cancer mortality, but cardiovascular adverse events owing to chemotherapy and radiotherapy have greater impact on clinical outcome and quality of life in cancer patients and survivors. There are a wide variety of cardiovascular adverse events related to cancer therapy, and the opportunities requiring specialized care by cardiovascular experts are increasing in clinical practice. Under such circumstances, onco-cardiology is becoming very important as a new discipline and attracting much attention in Japan.

Rat IgG (Fc)-Biotin Conjuagte (isotype control), purified
20005-1-FC-B	Alpha Diagnostics	0.1 mg	EUR 225

Rat IgG (Fc)-FITC Conjuagte (isotype control), purified
20005-1-FC-F	Alpha Diagnostics	0.1 mg	EUR 225

Rat IgG (Fc)-HRP Conjuagte (isotype control), purified
20005-1-FC-HP	Alpha Diagnostics	0.1 mg	EUR 225

Human IgG (Fc) fragment, purified (>95%, low endotoxin)
20007-1-FC-LE	Alpha Diagnostics	100 ul	EUR 225

Recombinant Dkk-1 Protein (Thr 32-His 266) [Fc] [Avi]
VAng-1452Lsx-200g	Creative Biolabs	200 µg	EUR 3844
Description: Biotinylated Human Dkk-1, Fc tag and Avi tag, is expressed in HEK 293 cells. (Uniprot ID: O94907-1)

Recombinant Dkk-1 Protein (Thr 32-His 266) [Fc] [Avi]
VAng-1452Lsx-25g	Creative Biolabs	25 µg	EUR 1013
Description: Biotinylated Human Dkk-1, Fc tag and Avi tag, is expressed in HEK 293 cells. (Uniprot ID: O94907-1)

Sheep IgG-Fc ELISA Kit, 96 tests, Quantitative
7615-Fc	Alpha Diagnostics	1 kit	EUR 712

Horse IgG-Fc ELISA Kit, 96 tests, Quantitative
7715-Fc	Alpha Diagnostics	1 kit	EUR 712

Dog IgG (Fc) fragment (isotype control, non-immune), purified
20016-FC	Alpha Diagnostics	0.5 mg	EUR 250

Human IgG Fc-Biotin conjugate (isotype control, non-immune), purified
20007-1-Fc-B	Alpha Diagnostics	0.1 mg	EUR 164

Human IgG Fc-FITC conjugate (isotype control, non-immune), purified
20007-1-Fc-F	Alpha Diagnostics	0.1 mg	EUR 164

Human IgG Fc-HRP conjugate (isotype control, non-immune), purified
20007-1-Fc-HP	Alpha Diagnostics	0.1 mg	EUR 164

Dkk-1 Polyclonal Antibody
ES4292-50ul	ELK Biotech	50ul	EUR 207
Description: A Rabbit Polyclonal antibody against Dkk-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Dkk-1 Polyclonal Antibody
ES4292-100ul	ELK Biotech	100ul	EUR 279
Description: A Rabbit Polyclonal antibody against Dkk-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Dkk-1 Polyclonal Antibody
ABP53293-003ml	Abbkine	0.03ml	EUR 158
Description: A polyclonal antibody for detection of Dkk-1 from Human, Mouse, Rat. This Dkk-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Dkk-1

Dkk-1 Polyclonal Antibody
ABP53293-01ml	Abbkine	0.1ml	EUR 289
Description: A polyclonal antibody for detection of Dkk-1 from Human, Mouse, Rat. This Dkk-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Dkk-1

Dkk-1 Polyclonal Antibody
ABP53293-02ml	Abbkine	0.2ml	EUR 414
Description: A polyclonal antibody for detection of Dkk-1 from Human, Mouse, Rat. This Dkk-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Dkk-1

Anti-Dkk-1 antibody
STJ97257	St John's Laboratory	200 µl	EUR 197
Description: Rabbit polyclonal to Dkk-1.

Anti-Dkk-1 antibody
STJ98000	St John's Laboratory	100 µl	EUR 234
Description: Mouse monoclonal to Dkk-1.

Dkk-1 Polyclonal Antibody
41928-100ul	SAB	100ul	EUR 252

Dkk-1 Polyclonal Antibody
41928-50ul	SAB	50ul	EUR 187

DKK-1 Recombinant Protein
40-225-0002mg	ProSci	0.002 mg	EUR 259.25
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues.

DKK-1 Recombinant Protein
40-225-001mg	ProSci	0.01 mg	EUR 364.25
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues.

DKK 1 Recombinant Protein
96-236	ProSci	0.1 mg	EUR 626.75
Description: Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway, binds to LRP6 with high affinity and prevents the Frizzled-Wnt-LRP6 complex formation in response to Wnts. DKK1 promotes LRP6 internalization and degradation when it forms a ternary complex with the cell surface receptor Kremen.DKK1 not olny functions as a head inducer during development, but also regulates joint remodeling and bone formation, which suggests roles for DKK1 in the pathogenesis of rheumatoid arthritis and multiple myeloma. More recently research reported, DKK1 impacts eye development from a defined developmental time point on, and is critical for lens separation from the surface ectoderm via β-catenin mediated Pdgfrα and E-cadherin expression.

DKK 1 Recombinant Protein
96-237	ProSci	0.025 mg	EUR 516.5
Description: Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway, binds to LRP6 with high affinity and prevents the Frizzled-Wnt-LRP6 complex formation in response to Wnts. DKK1 promotes LRP6 internalization and degradation when it forms a ternary complex with the cell surface receptor Kremen.DKK1 not olny functions as a head inducer during development, but also regulates joint remodeling and bone formation, which suggests roles for DKK1 in the pathogenesis of rheumatoid arthritis and multiple myeloma. More recently research reported, DKK1 impacts eye development from a defined developmental time point on, and is critical for lens separation from the surface ectoderm via β-catenin mediated Pdgfrα and E-cadherin expression.

Dkk-1 Recombinant Protein
96-861	ProSci	0.1 mg	EUR 542.75
Description: Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway, binds to LRP6 with high affinity and prevents the Frizzled-Wnt-LRP6 complex formation in response to Wnts. DKK1 promotes LRP6 internalization and degradation when it forms a ternary complex with the cell surface receptor Kremen.DKK1 not olny functions as a head inducer during development, but also regulates joint remodeling and bone formation, which suggests roles for DKK1 in the pathogenesis of rheumatoid arthritis and multiple myeloma. More recently research reported, DKK1 impacts eye development from a defined developmental time point on, and is critical for lens separation from the surface ectoderm via beta-catenin mediated Pdgfralpha and E-cadherin expression.

Dkk-1 Recombinant Protein
96-990	ProSci	0.05 mg	EUR 595.25
Description: Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway, binds to LRP6 with high affinity and prevents the Frizzled-Wnt-LRP6 complex formation in response to Wnts. DKK1 promotes LRP6 internalization and degradation when it forms a ternary complex with the cell surface receptor Kremen.DKK1 not olny functions as a head inducer during development, but also regulates joint remodeling and bone formation, which suggests roles for DKK1 in the pathogenesis of rheumatoid arthritis and multiple myeloma. More recently research reported, DKK1 impacts eye development from a defined developmental time point on, and is critical for lens separation from the surface ectoderm via beta-catenin mediated Pdgfralpha and E-cadherin expression.

IGF-1-Fc
E13-m003-1	EnoGene	10μg	EUR 291

Dkk-2
GT15222	Neuromics	100 ug	EUR 526

Recombinant (HEK) Rabbit IgG (Fc) (101-323aa, 185Thr/Asn284Ser, ~33 kda, >95%, Low Endotoxin)
20009-1-R-FC	Alpha Diagnostics	50 ug	EUR 286

Recombinant Mouse Dkk-1 Protein
RP01062	Abclonal	5 μg	EUR 183

Recombinant Human DKK-1 Protein
PROTO94907-3	BosterBio	10ug	EUR 317
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues.

DKK-1 (CHO-expressed), Mouse
HY-P7154	MedChemExpress	50ug	EUR 762

DKK-1 (HEK293-expressed), Human
HY-P7155A	MedChemExpress	50ug	EUR 843

Dkk-1 Polyclonal Conjugated Antibody
C41928	SAB	100ul	EUR 397

DKK-1 ELISA KIT|Human
EF000090	Lifescience Market	96 Tests	EUR 689

Human DKK-1 ELISA kit
LF-EK50797	Abfrontier	1×96T	EUR 648

Human IgG (Fc) fragment-Biotin purified (>95%, low endotoxin)
20007-1-FC-LE-B	Alpha Diagnostics	25 ug	EUR 286

Goat IgG (fc)-Biotin conjugate (isotype control)
20011-Fc-B	Alpha Diagnostics	100 ug	EUR 164

Goat IgG (fc)-FITC conjugate (isotype control)
20011-Fc-F	Alpha Diagnostics	100 ug	EUR 164

Goat IgG (fc)-HRP conjugate (isotype control)
20011-Fc-HP	Alpha Diagnostics	100 ug	EUR 164

FC 131
B7647-1	ApexBio	1 mg	EUR 187

Dkk-3 antibody
22898-100ul	SAB	100ul	EUR 390

Dog IgG (Fc) fragment (isotype control, non-immune), purified
20016-3-FC	Alpha Diagnostics	0.5 mg	EUR 250

Human DKK-1 PicoKine ELISA Kit
EK0867	BosterBio	96 wells	EUR 425
Description: For quantitative detection of human DKK1 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

ELISA kit for Human DKK-1
EK5390	SAB	96 tests	EUR 553
Description: Enzyme-linked immunosorbent assay kit for quantification of Human DKK-1 in samples from serum, plasma, tissue homogenates and other biological fluids.

ELISA kit for Rat DKK-1
EK5668	SAB	96 tests	EUR 553
Description: Enzyme-linked immunosorbent assay kit for quantification of Rat DKK-1 in samples from serum, plasma, tissue homogenates and other biological fluids.

Human CellExp? DKK-1, Human Recombinant
7132-10	Biovision		EUR 278

Human CellExp? DKK-1, Human Recombinant
7132-50	Biovision		EUR 1132

Dog IgG Fc-Biotin Conjugate (isotype control, non-immune), purified
20016-FC-B	Alpha Diagnostics	0.1 mg	EUR 225

Dog IgG Fc-FITC Conjugate (isotype control, non-immune), purified
20016-FC-F	Alpha Diagnostics	0.1 mg	EUR 225

Dog IgG Fc-HRP Conjugate (isotype control, non-immune), purified
20016-FC-HP	Alpha Diagnostics	0.1 mg	EUR 225

OPG-Fc Osteoprotegerin Human Recombinant Protein /Fc Chimera
PROTO00300-1	BosterBio	Regular: 50ug	EUR 317
Description: Recombinant OPG produced in yeast contains 2x412 amino acid residues, including 180 residues from mature OPG (a.a 22-201) and 232 residues from the Fc protein of human IgG1, and has a calculated molecular mass of 109.6kDa.

SCF-Fc
E13-m004-1	EnoGene	10μg	EUR 343

Recombinant (HEK) Human IgG3-Fc (99-377aa, His-tag, >95%, low endotoxin)
20007-G3-FC	Alpha Diagnostics	50 ug	EUR 286

Dkk-3 Polyclonal Antibody
ES5541-100ul	ELK Biotech	100ul	EUR 279
Description: A Rabbit Polyclonal antibody against Dkk-3 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

Dkk-3 Polyclonal Antibody
ES5541-50ul	ELK Biotech	50ul	EUR 207
Description: A Rabbit Polyclonal antibody against Dkk-3 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

Dkk-3 Polyclonal Antibody
ABP54542-003ml	Abbkine	0.03ml	EUR 158
Description: A polyclonal antibody for detection of Dkk-3 from Human, Mouse. This Dkk-3 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Dkk-3 at AA rangle: 80-160

Dkk-3 Polyclonal Antibody
ABP54542-01ml	Abbkine	0.1ml	EUR 289
Description: A polyclonal antibody for detection of Dkk-3 from Human, Mouse. This Dkk-3 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Dkk-3 at AA rangle: 80-160

Dkk-3 Polyclonal Antibody
ABP54542-02ml	Abbkine	0.2ml	EUR 414
Description: A polyclonal antibody for detection of Dkk-3 from Human, Mouse. This Dkk-3 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Dkk-3 at AA rangle: 80-160

Anti-Dkk-3 antibody
STJ98001	St John's Laboratory	100 µl	EUR 234
Description: Mouse monoclonal to Dkk-3.

Anti-Dkk-3 antibody
STJ92720	St John's Laboratory	200 µl	EUR 197
Description: Rabbit polyclonal to Dkk-3.

DKK-2 Recombinant Protein
40-651	ProSci	2 ug	EUR 259.25
Description: The dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 - 4, along with the distantly-related DKK family member DKK-11 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains. Playing an important regulatory role in vertebrate development through localized inhibition of Wnt-regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt/β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. DKK-2 has been shown to both inhibit and enhance canonical Wnt signaling; enhancing Wnt signaling through direct high-affinity binding of DKK-2 to LRP6 during LRP6 overexpression, while inhibiting Wnt signaling and promoting LRP6 internalization through the formation of a ternary complex between DKK-2, LRP6, and Kremen-2. Recombinant Human DKK-2 expressed in CHO cells is a glycoprotein that has a calculated molecular weight of 25.8 kDa and contains 234 amino acid residues. Due to glycosylation, human DKK-2 migrates at an apparent molecular weight of approximately 31-36 kDa by SDS-PAGE analysis under non-reducing conditions.

DKK-3 Recombinant Protein
40-652	ProSci	2 ug	EUR 259.25
Description: The dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 - 4, along with the distantly-related DKK family member DKK-L1 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains. Playing an important regulatory role in vertebrate development through localized inhibition of Wnt-regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt/β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. DKK-3 has been shown to potentiate, rather than inhibit, Wnt signaling through interactions with the high-affinity, transmembrane co-receptors Kremen-1 (Krm1) and Kremen-2 (Krm2). Recombinant Human DKK-3 expressed in CHO cells is a glycoprotein that has a calculated molecular weight of 36.3 kDa and contains 329 amino acid residues. Due to glycosylation, Human DKK-3 migrates at an apparent molecular weight of approximately 39-49 kDa by SDS-PAGE analysis under non-reducing conditions.

DKK 3 Recombinant Protein
96-239	ProSci	0.2 mg	EUR 684.5
Description: Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK3 has been proposed as tumour suppressor gene and a marker for tumour blood vessels. DKK3 is the only DKK family member abundantly expressed in normal lung, but silenced by promoter hypermethylation in a large fraction of lung cancer cell lines and lung tumors. Downregulation of DKK3 was correlated with tumor progression and expression of nuclear beta-catenin in lung tumors. Ectopic expression of DKK3 in lung cancer cells with DKK3 hypermethylation induced apoptosis and inhibited TCF-4 activity as well as nuclear accumulation of beta-catenin and expression of TCF-4 targets c-Myc and cyclin D1. DKK3 modulates FGF and Activin/Nodal signaling to regulate mesoderm induction during early Xenopus development, was reported.

Dkk-3 Recombinant Protein
96-991	ProSci	0.05 mg	EUR 542.75
Description: Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK3 has been proposed as tumour suppressor gene and a marker for tumour blood vessels. DKK3 is the only DKK family member abundantly expressed in normal lung, but silenced by promoter hypermethylation in a large fraction of lung cancer cell lines and lung tumors. Downregulation of DKK3 was correlated with tumor progression and expression of nuclear beta-catenin in lung tumors. Ectopic expression of DKK3 in lung cancer cells with DKK3 hypermethylation induced apoptosis and inhibited TCF-4 activity as well as nuclear accumulation of beta-catenin and expression of TCF-4 targets c-Myc and cyclin D1. DKK3 modulates FGF and Activin/Nodal signaling to regulate mesoderm induction during early Xenopus development, was reported.

Recombinant Human Dickkopf-Related Protein 2/DKK-2 (N-Fc, C-6His)
CC49-10ug	Novoprotein	10ug	EUR 156
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.2.

Recombinant Human Dickkopf-Related Protein 2/DKK-2 (N-Fc, C-6His)
CC49-1mg	Novoprotein	1mg	EUR 2283
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.2.

Recombinant Human Dickkopf-Related Protein 2/DKK-2 (N-Fc, C-6His)
CC49-500ug	Novoprotein	500ug	EUR 1613
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.2.

Recombinant Human Dickkopf-Related Protein 2/DKK-2 (N-Fc, C-6His)
CC49-50ug	Novoprotein	50ug	EUR 369
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.2.

Human DKK-1 ELISA kit (4×96T)
LF-EK50798	Abfrontier	4×96T	EUR 2201

Nori® Human DKK-1 ELISA Kit
GR106268	Genorise Scientific	96-well	EUR 461

Recombinant (HEK) Human IgG1 Fc (103Cys/Ser, 99-330aa, His-tag, >95%, low endotoxin)
20007-G1-FC	Alpha Diagnostics	50 ug	EUR 286

Recombinant (HEK) Human IgG2-Fc (257Ser/Ala, 99-327aa, His-tag, >95%, low endotoxin)
20007-G2-FC	Alpha Diagnostics	50 ug	EUR 286

Recombinant (HEK) Human IgG4-Fc (108Ser/Pro, 99-327aa, His-tag, >95%, low endotoxin)
20007-G4-FC	Alpha Diagnostics	50 ug	EUR 286

Recombinant (HEK) Mouse IgG2a-Fc (98-330aa, ~34 kda, His-tag, >95%, low endotoxin)
20102-102-FC	Alpha Diagnostics	50 ug	EUR 286

Recombinant (HEK) Mouse IgG2b-Fc (97-335aa, ~37 kda, His-tag, >95%, low endotoxin)
20102-103-FC	Alpha Diagnostics	50 ug	EUR 286

Recombinant (HEK) Mouse IgG3-Fc (97-329aa, ~33 kda, His-tag, >95%, low endotoxin)
20102-104-FC	Alpha Diagnostics	50 ug	EUR 286

Recombinant Human CD47 Protein, His-Fc (IgG), Insect-10ug
QP11336-HIS-Fc-10ug	EnQuireBio	10ug	EUR 201

SDF-1α-Fc
E13-m001-1	EnoGene	10μg	EUR 291

VEGF-121-Fc
E13-m005-1	EnoGene	10μg	EUR 343

VEGF-165-Fc
E13-m006-1	EnoGene	10μg	EUR 343

IL-2-Fc
E13-m007-1	EnoGene	10μg	EUR 310

Recombinant (HEK) Mouse IgG1-Fc (98-321aa, 102Cys/Ser, ~32 kda, His-tag, >95%, low endotoxin)
20102-101-FC	Alpha Diagnostics	50	EUR 286

PinPoint-FC attP Placement Vector
PIN300A-1	SBI	10ug	EUR 778

Human DKK-1(Dickkopf-related protein 1) ELISA Kit
EH0113	FN Test	96T	EUR 524.1
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 18.75pg/ml

Recombinant Human Dkk-3 Protein
RP00355	Abclonal	10 μg	EUR 164

DKK-3 ELISA KIT|Human
EF000091	Lifescience Market	96 Tests	EUR 689

Dkk-1 ELISA Kit (Human) : 96 Wells (OKAG00221)
OKAG00221	Aviva Systems Biology	96 Wells	EUR 596
Description: Description of target: This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.;Species reactivity: Human;Application: ELISA;Assay info: Quantitative Colorimentric Sandwich ELISA;Sensitivity: 63 pg/mL

FLT4-Fc Vascular Endothelial Growth Factor Receptor-3 Fc Chimera Human Recombinant Protein
PROTP35916-1	BosterBio	Regular: 10ug	EUR 317
Description: Soluble FLT4 Human Recombinant fused with the Fc part of human IgG1 produced in baculovirus is a monomeric, glycosylated, polypeptide containing 774 amino acids and having a molecular mass of 260 kDa. The soluble receptor protein contains only the first 7 extracellular domains, which contain all the information necessary for ligand binding.;The FLT4 Fc Chimera is purified by proprietary chromatographic techniques.

Recombinant Human FGFR1a (IIIc) Fc Protein
PROTP11362-1	BosterBio	50ug	EUR 317
Description: The FGF family plays a central role during prenatal development and postnatal growth, and the regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. The FGF ligands bind to a family of type I transmembrane tyrosine kinase receptors which leads to dimerization and activation by sequential autophosphorylation of specific tyrosine residues. Four genes encoding structurally related FGF receptors (FGFR-1 to -4) are known. Alternative splicing of the mRNAs generates numerous multiple forms of FGFR-1 to -3. Alternate forms of FGF receptors can exhibit different specificities with respect to ligand binding. For example, the form designated as FGFR1a (IIc) interacts predominantly with FGF-acidic (FGF1) and FGF-basic (FGF2). A frequent splicing event involving FGFR-1 and -2 results in receptors containing all three Ig domains, referred to as the alpha isoform, or only IgII and IgIII, referred to as the beta isoform. Only the alpha isoform has been identified for FGFR-3 and FGFR-4. Additional splicing events for FGFR-1 to -3, involving the C-terminal half of the IgIII domain encoded by two mutually exclusive alternative exons, generate FGF receptors with alternative IgIII domains (IIIb and IIIc). Recombinant human FGFR1a (IIIc) is a 65.2 kDa protein containing 586 amino acids. Under reducing conditions, FGFR1a migrates between 100-110 kDa on SDS-PAGE gel.

TNFRSF14 HVEM-Fc Human Recombinant Protein
PROTO43557-1	BosterBio	Regular: 100ug	EUR 317
Description: TNFRSF14 Human Recombinant produced in Pichia Pastoris is a single, glycosylated, polypeptide chain containing 396 amino acids and having a molecular mass of 58.0kDa.

Recombinant Dkk-1 Protein (Thr 32-His 266) [His]
VAng-1453Lsx-100g	Creative Biolabs	100 µg	EUR 1013
Description: Human Dkk-1, His tag, is expressed in HEK 293 cells. (Uniprot ID: NP_036374.1)

Recombinant Dkk-1 Protein (Thr 32-His 266) [His]
VAng-1453Lsx-1mg	Creative Biolabs	1 mg	EUR 4999
Description: Human Dkk-1, His tag, is expressed in HEK 293 cells. (Uniprot ID: NP_036374.1)

Recombinant Dkk-1 Protein (Thr 32-His 266) [Strep]
VAng-1454Lsx-1mg	Creative Biolabs	1 mg	EUR 6374
Description: Human Dkk-1, Fc tag, is expressed in HEK 293 cells. (Uniprot ID: NP_036374.1)

Recombinant Dkk-1 Protein (Thr 32-His 266) [Strep]
VAng-1454Lsx-250g	Creative Biolabs	250 µg	EUR 2470
Description: Human Dkk-1, Fc tag, is expressed in HEK 293 cells. (Uniprot ID: NP_036374.1)

Recombinant Dkk-1 Protein (Thr 32-His 266) [Strep]
VAng-1454Lsx-25g	Creative Biolabs	25 µg	EUR 765
Description: Human Dkk-1, Fc tag, is expressed in HEK 293 cells. (Uniprot ID: NP_036374.1)

Recombinant Dkk-1 Protein (Thr 32-His 272) [His]
VAng-1455Lsx-500g	Creative Biolabs	500 µg	EUR 4449
Description: Mouse Dkk-1, His tag, is expressed in HEK 293 cells. (Uniprot ID: O54908)

Recombinant Dkk-1 Protein (Thr 32-His 272) [His]
VAng-1455Lsx-50g	Creative Biolabs	50 µg	EUR 1013
Description: Mouse Dkk-1, His tag, is expressed in HEK 293 cells. (Uniprot ID: O54908)

Nori® Human DKK-1 ELISA Kit (2 plates)
GR106268-2	Genorise Scientific	2 x 96-well	EUR 832

Human EPOR / Erythropoietin Receptor Protein (Fc Tag)
G1011-.1	ApexBio	100 µg	EUR 696

Recombinant Human Dkk-3/DKK3 Protein
RP00209	Abclonal	10 μg	EUR 155

Human DKK-4 PicoKine ELISA Kit
EK0868	BosterBio	96 wells	EUR 455
Description: For Quantitative Detection of human DKK-4 in cell culture supernates, serum and plasma(heparin, EDTA).

DKK-3 ELISA Kit (Human) (OKBB00603)
OKBB00603	Aviva Systems Biology	96 Wells	EUR 505
Description: Description of target: Dickkopf-related protein 3 is a protein that in humans is encoded by the DKK3 gene. This gene encodes a protein that is a member of the dickkopf family. It is mapped to 11p15.3. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Members of the Dkk-related family display unique patterns of mRNA expression in human and mouse tissues, and are secreted when expressed in 293T cells. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: <= 10 pg/mL

IGF-1-Fc
E13-m003-2	EnoGene	50μg	EUR 830

TEK Tyrosine Kinase Endothelial Fc Chimera Mouse Recombinant Protein
PROTQ02858-1	BosterBio	Regular: 10ug	EUR 317
Description: Soluble TEK Mouse Recombinant fused with the Fc part of human IgG1 produced in CHO is a glycosylated disulfide-linked homodimer, polypeptide containing amino acids 119-740 amino acids and having a total molecular mass of 280 kDa. Mouse TIE-2/Fc monomer has a calculated molecular mass of approximately 105 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 140 kDa protein in SDS-PAGE under reducing conditions.;The TEK Fc Chimera is purified by proprietary chromatographic techniques.

FGFR2 Fibroblast Growth Factor Receptor 2 Fc ChimeraHuman Recombinant Protein
PROTP21802-1	BosterBio	Regular: 10ug	EUR 317
Description: Soluble FGFR-2a (IIIc) Fc Chimera Human Recombinant fused with Xa cleavage site with the Fc part of human IgG1 produced in baculovirus is a heterodimeric, glycosylated, Polypeptide chain and having a molecular mass of 195 kDa. ;The FGFR2 is purified by proprietary chromatographic techniques.

Contactin-1, FC Chimera
PR15072	Neuromics	100 ug	EUR 474

TIE-1 Fc Chimera
PR27153	Neuromics	2 ug	EUR 191

Plastic Columns Frits
FC-100	ABTBeads	100/pk	EUR 122

Plastic Columns Frits
FC-50	ABTBeads	50/pk	EUR 83

FGFR4 Fibroblast Growth Factor Receptor 4 Fc Chimera Human Recombinant Protein
PROTP22455-1	BosterBio	Regular: 10ug	EUR 317
Description: Soluble FGFR-4a (IIIc) Fc Chimera Human Recombinant fused with Xa cleavage site with the Fc part of human IgG1 produced in baculovirus is a heterodimeric, glycosylated, Polypeptide chain and having a molecular mass of 170 kDa. ;The FGFR4 is purified by proprietary chromatographic techniques.

Fc
EF006811	Lifescience Market	96 Tests	EUR 689

Fc
EF006812	Lifescience Market	96 Tests	EUR 689

Fc
EF006814	Lifescience Market	96 Tests	EUR 689

Fc
EF006815	Lifescience Market	96 Tests	EUR 689

The Japanese Onco-Cardiology Society was established in 2017, and continues integration of academic activities to solve challenging problems in this field. Interdisciplinary collaborations between cardiologists and oncologists will be further progressed in medical care, clinical and basic research, and education.